×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
GeneticVariation
BEFREE
CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma .27713153 2016
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma .28038705 2017
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Cyclin D1 -positive tumor cells are commonly found in mantle cell lymphoma but they are very rare in diffuse large B-cell lymphoma.28296741 2017
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 mRNA as a molecular marker for minimal residual disease monitoring in patients with mantle cell lymphoma .29273915 2018
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 -CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA.30180865 2018
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma .7670110 1995
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 messenger RNA overexpression as a marker for mantle cell lymphoma .7753558 1995
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma.7918073 1994
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 protein expression in mantle cell lymphoma .8573535 1995
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
bcl-1 rearrangement and cyclin D1 protein expression in mantle cell lymphoma .8774476 1996
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
PRAD1 /Cyclin D1 gene overexpression in mantle cell lymphoma .8907267 1996
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
GeneticVariation
BEFREE
Cyclin D1 was rarely expressed in lymphoid cell lines except in t(11;14)(q13;q32) -bearing B-cell malignancies and/or mantle cell lymphoma , which expressed cyclin D1 predominantly.9028328 1997
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow.9291459 1997
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Cyclin D1 expression in mantle cell lymphoma is accompanied by downregulation of cyclin D3 and is not related to the proliferative activity.9376597 1997
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Bcl-1 , altered in 12 cases, was highly specific to mantle cell lymphomas (57% of them), but 6 cases had a different histologic subtype.9573674 1998
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma .
21746927 2011
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
A novel bcl-1 /JH breakpoint from a patient affected by mantle cell lymphoma extends the major translocation cluster.
12015751 2002
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
A simple antigen retrieval method for the optimal demonstration of cyclin-D1 overexpression in formalin-fixed paraffin-embedded cases of mantle cell lymphoma .
16082258 2005
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Alterations of the cyclin D1 /p16-pRB pathway in mantle cell lymphoma .
9377576 1997
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
GeneticVariation
BEFREE
Although the observed break points in the BCL-1 locus are not tightly clustered, its rearrangement has been documented in 40-70% of cases of mantle cell lymphoma , whereas it only rarely occurs in other B cell lymphomas.
9234379 1997
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Among the quiescent genes activated by rearrangement, expression of cyclin D1 (due to rearrangement of the CCND1 [BCL-1 ] gene) is a near-specific marker of t(11;14) in mantle cell lymphoma ; BCL-2 expression distinguishes follicular lymphoma cells from their nonneoplastic counterparts in reactive germinal centers and appears to be an independent prognostic marker in diffuse large cell lymphoma; and TAL-1 (SCL) expression identifies T-cell acute lymphoblastic neoplasms in which this gene is activated.
11781220 2002
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 breakpoint locus demonstrates that half of the CCND1 breaks are near CpG dinucleotides.
22915650 2012
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
AlteredExpression
BEFREE
Analysis of cyclin D1 expression by quantitative real-time reverse transcription-polymerase chain reaction in the diagnosis of mantle cell lymphoma .
11863220 2002
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
GeneticVariation
BEFREE
Approximately 70% of centrocytic (mantle-cell) lymphomas have the chromosomal translocation t(11;14) (q13; q32) and associated rearrangements at the bcl-1 breakpoint locus and at the cyclin D1 (PRAD1 , CCND1 ) gene, thus implicating this gene in the pathogenesis of centrocytic lymphoma.
8172823 1994
×
Entrez Id: 595
Gene Symbol: CCND1
CCND1
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
0.400
Biomarker
BEFREE
As a consequence, the sole cyclin D1 positivity by immunohistochemistry may not be enough to distinguish pleomorphic/blastoid mantle cell lymphoma from diffuse large B-cell lymphoma.
21334716 2011