×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).
20522446 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
20609353 2010
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
In silico identification of significant detrimental missense mutations of EGFR and their effect with 4-anilinoquinazoline-based drugs.
19455431 2010
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.
19147750 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.
19358724 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.
19047918 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.
19147750 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.
19096302 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.
19396835 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations.
19671738 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.
18199554 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
18458038 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids.
18372921 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
17910045 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response.
18676761 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.
18594010 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.
18628075 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
19029981 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.
18794081 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Correlation of EGFR mutations with chromosomal alterations and expression of EGFR, ErbB3 and VEGF in tumor samples of lung adenocarcinoma patients.
18450321 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
17653080 2008
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor.
17545553 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.
17332249 2007
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.
18089823 2007
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Prognostic factors for gefitinib-treated postoperative recurrence in non-small cell lung cancer.
18176089 2007