Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.500 Therapeutic CTD_human Pulmonary emboli from pulse-spray and mechanical thrombolysis: evaluation with an animal dialysis-graft model. 8657906

1996
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.500 Therapeutic CTD_human Urokinase and AT-III concentrate treatment in inferior vena cava thrombosis associated with nephrotic syndrome. 2133253

1990
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.500 Therapeutic CTD_human [Treatment of massive arterial thrombosis caused by thrombocytopenia induced by heparin with local thrombolysis]. 2106299

1990
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.500 Therapeutic CTD_human Intraoperative infusion of lytic drugs for thrombotic complications of revascularization. 2795766

1989
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0040053
Disease: Thrombosis
Thrombosis 		0.500 Therapeutic CTD_human The urokinase-pulmonary embolism trial. 4884574

1969
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Matrigel invasion assays with two specific uPA inhibitors, B428 and p-aminobenzamidine, showed that invasion of a prostate cancer cell line containing uPA gene amplification was inhibited by these small-molecule uPA inhibitors, while invasion of prostate cell lines without uPA gene amplification were not. 16430655

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Is urokinase gene 3'-UTR polymorphism associated with prostate cancer? 17192053

2005
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Matrigel invasion assay showed that prostate cancer cell line PC-3, containing amplification of the uPA gene, was more sensitive to the urokinase inhibitor, amiloride, than DU145 or LNCaP cell lines, which do not have the amplification. 11454671

2001
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.390 Biomarker CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.380 Biomarker CTD_human Methylation status of the 32 randomly selected and 16 potential tumor-related genes was analyzed in 10 primary gastric cancers, and 42 genes (ABHD9, ADFP, ALDH1A3, ANXA5, AREG, BDNF, BMP7, CAV1, CDH2, CLDN3, CTSL, EEF1A2, F2R, FADS1, FSD1, FST, FYN, GPR54, GREM1, IGFBP3, IGFBP7, IRS2, KISS1, MARK1, MLF1, MSX1, MTSS1, NT5E, PAX6, PLAGL1, PLAU, PPIC, RBP4, RORA, SCRN1, TBX3, TFAP2C, TNFSF9, ULBP2, WIF1, ZNF177 and ZNF559) were methylated in at least one primary gastric cancer. 16367923

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.370 Biomarker CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.360 Biomarker CTD_human Amplification of the urokinase gene and the sensitivity of prostate cancer cells to urokinase inhibitors. 16430655

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.360 Biomarker CTD_human Is urokinase gene 3'-UTR polymorphism associated with prostate cancer? 17192053

2005
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.360 Biomarker CTD_human Amplification of urokinase gene in prostate cancer. 11454671

2001
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0004096
Disease: Asthma
Asthma 		0.340 Biomarker CTD_human Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. 21912604

2011
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.340 Biomarker CTD_human These results show that uPA is one of the downstream target genes induced by constitutively activated RelA in human pancreatic tumor cells, and suggests that constitutive RelA activity may play a critical role in tumor invasion and metastasis. 10467400

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.330 Biomarker CTD_human

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155

2016
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Therapeutic CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155

2016
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Biomarker CTD_human In the present study, we investigated the therapeutic effects of uPA gene-modified BDLSC transplantation on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. 18481824

2008
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.320 Therapeutic CTD_human In the present study, we investigated the therapeutic effects of uPA gene-modified BDLSC transplantation on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. 18481824

2008
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.320 Therapeutic CTD_human The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy. 18491991

2008
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Therapeutic CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155

2016
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Biomarker CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155

2016