×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry.
22495361 2012
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.
23047549 2012
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
21155762 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
21056691 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
22006311 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Challenges in the identification of MSH6-associated colorectal cancer: rectal location, less typical histology, and a subset with retained mismatch repair function.
21836479 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome.
21642682 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Challenges in the identification of MSH6-associated colorectal cancer: rectal location, less typical histology, and a subset with retained mismatch repair function.
21836479 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.
19851887 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
20028993 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer.
20487569 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
20028993 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers.
20587412 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
18566915 2009
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
18566915 2009
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
18301448 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutation spectrum in HNPCC in the Israeli population.
18389388 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
A high incidence of MSH6 mutations in Amsterdam criteria II-negative families tested in a diagnostic setting.
18625694 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Feasibility of screening for Lynch syndrome among patients with colorectal cancer.
18809606 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts.
18269114 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
17453009 2007
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
17453009 2007
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor.
16418736 2006
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.
16807412 2006
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.
16283884 2005