×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Liver neoplasms
0.700
Biomarker
CTD_human
The incidence of KRAS2 mutations in human compared to mouse lung tumors differed significantly, as did the incidence of Hras and p53 gene mutations in human compared to mouse liver tumors .
16410370 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Liver neoplasms
0.700
Biomarker
CTD_human
Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver.
12378512 2002
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Liver neoplasms
0.690
Biomarker
CTD_human
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
27064257 2016
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Liver neoplasms
0.690
Biomarker
CTD_human
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
16317707 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Liver neoplasms
0.690
Biomarker
CTD_human
Abnormalities of the ARF-p53 pathway in primary angiosarcomas of the liver.
12378512 2002
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Liver neoplasms
0.660
Biomarker
CTD_human
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.
12211074 2002
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Liver neoplasms
0.660
Biomarker
CTD_human
Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species.
10629081 2000
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Liver neoplasms
0.600
Biomarker
CTD_human
Hence, chloroform prevented the hypomethylation and increased mRNA expression of the c-myc gene and the promotion of liver tumors by DCA, while enhancing DCA-promotion of kidney tumors.
11532874 2001
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Liver neoplasms
0.600
Biomarker
CTD_human
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
8807143 1996
×
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
Liver neoplasms
0.580
Biomarker
CTD_human
Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells.
29134746 2018
×
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
Liver neoplasms
0.580
Biomarker
CTD_human
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
20143881 2010
×
Entrez Id: 7015
Gene Symbol: TERT
TERT
Liver neoplasms
0.550
Biomarker
CTD_human
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
27064257 2016
×
Entrez Id: 27232
Gene Symbol: GNMT
GNMT
Liver neoplasms
0.550
Biomarker
CTD_human
Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver.
21137059 2010
×
Entrez Id: 324
Gene Symbol: APC
APC
Liver neoplasms
0.540
Biomarker
CTD_human
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
27064257 2016
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Liver neoplasms
0.540
Biomarker
CTD_human
Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice.
12127304 2002
×
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
Liver neoplasms
0.530
Biomarker
CTD_human
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
8807143 1996
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Liver neoplasms
0.520
Biomarker
CTD_human
Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
30556042 2018
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Liver neoplasms
0.520
Biomarker
CTD_human
Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling.
29142166 2017
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Liver neoplasms
0.520
Biomarker
CTD_human
Suppression of autophagic flux by bile acids in hepatocytes.
24189133 2014
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Liver neoplasms
0.520
Biomarker
CTD_human
Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.
23178280 2013
×
Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Liver neoplasms
0.520
Biomarker
CTD_human
Mechanisms of STAT3 activation in the liver of FXR knockout mice.
24091600 2013
×
Entrez Id: 2272
Gene Symbol: FHIT
FHIT
Liver neoplasms
0.510
Biomarker
CTD_human
Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
12112319 2002
×
Entrez Id: 440
Gene Symbol: ASNS
ASNS
Liver neoplasms
0.500
Biomarker
CTD_human
Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.
28108177 2017
×
Entrez Id: 196
Gene Symbol: AHR
AHR
Liver neoplasms
0.400
Biomarker
CTD_human
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.
30346592 2019
×
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
Liver neoplasms
0.400
Biomarker
CTD_human
Preliminary evidence supported a role for the constitutive androstane receptor (CAR ) in the mode of action of toxaphene-induced mouse liver tumors .
28218408 2017