Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.900 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.900 CausalMutation CLINVAR Nonsense-mediated mRNA decay: terminating erroneous gene expression. 15145354

2004
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.900 CausalMutation CLINVAR

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.900 GeneticVariation CLINVAR

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. 22271473

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Epidermal growth factor receptor blockers for the treatment of ovarian cancer. 21975775

2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. 20177704

2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR The PI3K pathway as drug target in human cancer. 20085938

2010
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR PIK3CA mutation associates with improved outcome in breast cancer. 19671852

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. 19358724

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918

2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR PTEN and the PI3-kinase pathway in cancer. 18767981

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Profound growth inhibition and apoptosis were observed in CI-1040-treated cancer cells with mutations in either KRAS or BRAF in comparison with the ovarian cancer cells containing wild-type sequences. 19018267

2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. 17910045

2008
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer. 18371219

2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 17332249

2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. 16353168

2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205

2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Somatic PTPN11 mutations in childhood acute myeloid leukaemia. 15842656

2005
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370

2005
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Nonsense-mediated mRNA decay: terminating erroneous gene expression. 15145354

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. 11504908

2001
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 GeneticVariation CLINVAR

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 CausalMutation CLINVAR

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.700 GeneticVariation CLINVAR