Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0406811
Disease: Reticulate acropigmentation of Kitamura
Reticulate acropigmentation of Kitamura 		0.720 Biomarker GENOMICS_ENGLAND Sanger sequencing of four additional unrelated RAK patients revealed four additional ADAM10 mutations. 23666529

2013
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0406811
Disease: Reticulate acropigmentation of Kitamura
Reticulate acropigmentation of Kitamura 		0.720 GermlineCausalMutation ORPHANET Sanger sequencing of four additional unrelated RAK patients revealed four additional ADAM10 mutations. 23666529

2013
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0406811
Disease: Reticulate acropigmentation of Kitamura
Reticulate acropigmentation of Kitamura 		0.720 GeneticVariation UNIPROT Sanger sequencing of four additional unrelated RAK patients revealed four additional ADAM10 mutations. 23666529

2013
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0406811
Disease: Reticulate acropigmentation of Kitamura
Reticulate acropigmentation of Kitamura 		0.720 Biomarker CTD_human

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C3810041
Disease: ALZHEIMER DISEASE 18
ALZHEIMER DISEASE 18 		0.600 GeneticVariation UNIPROT ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. 24055016

2013
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C3810041
Disease: ALZHEIMER DISEASE 18
ALZHEIMER DISEASE 18 		0.600 GeneticVariation UNIPROT Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. 19608551

2009
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C3810041
Disease: ALZHEIMER DISEASE 18
ALZHEIMER DISEASE 18 		0.600 Biomarker CTD_human

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263

2006
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263

2006
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.320 Biomarker CTD_human We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.310 Biomarker CTD_human We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD) 		0.310 Biomarker CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263

2006
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C3714534
Disease: dowling-degos disease
dowling-degos disease 		0.310 Biomarker CTD_human

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Biomarker CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Biomarker CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047

2019
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263

2006
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263

2006
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C1321872
Disease: Stage IV Skin Melanoma
Stage IV Skin Melanoma 		0.300 GeneticVariation UNIPROT

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C4552092
Disease: Dowling-Degos disease 1
Dowling-Degos disease 1 		0.300 Biomarker CTD_human