Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker CTD_human Characterisation of acetylcholinesterase release from neuronal cells. 23047022

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker CTD_human In experiments with cultured HEK293T cells, we show here that GSK3β stabilizes synaptic acetylcholinesterase (AChE-S), a critical component of AD development. 22944069

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.400 Biomarker CTD_human Characterisation of acetylcholinesterase release from neuronal cells. 23047022

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker CTD_human Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β. 22944069

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker CTD_human Characterisation of acetylcholinesterase release from neuronal cells. 23047022

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.400 Biomarker CTD_human Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. 18599028

2008
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.350 Biomarker CTD_human Repeated exposure to sublethal doses of the organophosphorus compound VX activates BDNF expression in mouse brain. 22240983

2012
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.340 Biomarker CTD_human Previous studies indicate that the regions, where the ACHE (7q22) and BCHE (3q26.1-q26.2) genes are localized, are suffering such structural modifications in breast cancer. 23063927

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.340 Biomarker CTD_human Previous studies indicate that the regions, where the ACHE (7q22) and BCHE (3q26.1-q26.2) genes are localized, are suffering such structural modifications in breast cancer. 23063927

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0036572
Disease: Seizures
Seizures 		0.330 Biomarker CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0036572
Disease: Seizures
Seizures 		0.330 Therapeutic CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0036572
Disease: Seizures
Seizures 		0.330 Therapeutic CTD_human Our findings suggest that seizures caused cognitive dysfunction and a decrease of ChAT and AChE activities that might be related, at least in part, to the neurological problems presented by seizures induced by pilocarpine. 19941057

2010
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0036572
Disease: Seizures
Seizures 		0.330 Biomarker CTD_human Our findings suggest that seizures caused cognitive dysfunction and a decrease of ChAT and AChE activities that might be related, at least in part, to the neurological problems presented by seizures induced by pilocarpine. 19941057

2010
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0028754
Disease: Obesity
Obesity 		0.320 Biomarker CTD_human We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. 29273807

2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.320 Biomarker CTD_human Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β. 22944069

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.320 Biomarker CTD_human Characterisation of acetylcholinesterase release from neuronal cells. 23047022

2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.310 Biomarker CTD_human Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure. 29644616

2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.310 Biomarker CTD_human Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure. 29644616

2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.310 Therapeutic CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.310 Biomarker CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C4048158
Disease: Convulsions
Convulsions 		0.310 Biomarker CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C4048158
Disease: Convulsions
Convulsions 		0.310 Therapeutic CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141

2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker PSYGENET Omega-3 fatty acids prevent the ketamine-induced increase in acetylcholinesterase activity in an animal model of schizophrenia. 25498892

2015
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.310 Biomarker CTD_human Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. 19941057

2010
Entrez Id: 43
Gene Symbol: ACHE
ACHE
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.310 Therapeutic CTD_human Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. 19941057

2010