Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. 31016362

2019
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis. 30703374

2019
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. 31016362

2019
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis. 30703374

2019
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218

2018
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway. 29353218

2018
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. 27099261

2017
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. 27099261

2017
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation. 25488910

2015
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation. 25488910

2015
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. 25139994

2014
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 24342267

2014
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. 25139994

2014
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 24342267

2014
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats. 20409916

2013
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. 22335191

2013
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. 22335191

2013
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats. 20409916

2013
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. 22291909

2012
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling. 22291909

2012
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. 20811386

2010
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. 20616315

2010
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic CTD_human Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. 20429690

2010
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. 20616315

2010
Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker CTD_human Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. 20811386

2010