|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus has been identified as a potential etiological factor in schizophrenia.
|
16921496 |
2006 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia.
|
17448448 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Unfortunately, these studies have produced conflicting results.In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia.
|
17427186 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study sought to clarify the effects of the COMT Val158Met polymorphism on brain structure, function, and risk of developing schizophrenia in a well-characterized cohort of individuals at high risk of schizophrenia for familial reasons.
|
17014827 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia.
|
17383818 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia.
|
17113268 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Aggression is associated with the 'low' activity allele (Met) of the functional Val158Met polymorphism among people with schizophrenia spectrum disorders relative to the 'high' activity (Val) allele.
|
18075475 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association was observed between schizophrenia, but not other related disorders, and genotypes GG (Val/Val) for rs4680 and TT for rs4633.
|
17363961 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common functional polymorphism (rs4680, Val158Met) has been extensively tested for an association with schizophrenia, but with conflicting results.
|
17482701 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on the results in our sample, the catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
|
17601704 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia.
|
17325717 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical deficits associated with the liability to schizophrenia remains controversial.
|
17516763 |
2007 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase (COMT) Val158Met polymorphism has been identified as a potential etiologic factor in schizophrenia.
|
18092319 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.
|
18988738 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings suggest that anhedonia is manifest in individuals who carry genetic liability for schizophrenia and is associated with the Val(158)Met polymorphism of the COMT gene.
|
19025226 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the V158M SNP of the COMT gene is not associated with TD in schizophrenia.
|
18424907 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of our study is to examine the association between Ala72Ser and Val158Met functional polymorphisms in COMT gene and homicidal behavior in schizophrenia.
|
18163386 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls.
|
18407467 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affect dopamine regulated prefrontal cortical activity during working memory (WM) tasks, and to weakly increase risk for developing schizophrenia.
|
17707347 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val158Met has been found to predict performance on dopamine-mediated prefrontal tasks in healthy adults and patients with schizophrenia.
|
17924258 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMT Val158Met polymorphism and aggressive schizophrenia case status in the Korean population.
|
18789857 |
2008 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the hypothesis that the COMT Val(158)Met polymorphism may be a modifier gene for the symptomatology of schizophrenia.
|
17850881 |
2008 |