rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS.
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22523565 |
2012 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors.
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25641599 |
2017 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results.
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19038252 |
2009 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Overall results suggest changes in neuromodulator levels are subtle in SOD1-G93A ALS mixed cell cultures.
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30618638 |
2018 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Therefore, the aim of this study was to investigate the effect of intravenous delivery of human IGF1 by self-complementary adeno-associated virus (scAAV) vectors in 90-day-old SOD1-G93A ALS mice.
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29499331 |
2018 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Therefore, we investigate the influence of the soluble factors released by hADSCs on the GLT1 in primary astrocytes cultured from SOD1(G93A) mice, a widely studied mutant human SOD1 transgenic model of ALS.
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20152807 |
2010 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
We report that symptomatic male hSOD1(G93A) transgenic mice exhibit a deficiency in GH secretion similar to that seen in human ALS.
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22621959 |
2012 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
To investigate the effect of specific and sustained IGF-1 expression in skeletal muscle or central nervous system on motor performance, life span, and motor neuron survival, human-IGF-1 transgenic mice were crossed with the G93A SOD-1 mutant model of ALS.
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17597610 |
2007 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Innate and adaptive immunity were investigated in the CNS of the Superoxide Dismutase 1 (SOD1)(G93A) transgenic mouse model of ALS.
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18997009 |
2008 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis (ALS), we transplanted hNPs or growth factor (GF)-expressing hNPs into the central nervous system (CNS) of mutant Cu/Zn superoxide dismutase (SOD1(G93A)) transgenic mice.
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19322031 |
2009 |
rs745805222
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Amyotrophic Lateral Sclerosis
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0.100 |
GeneticVariation
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BEFREE |
Finally, AAV9::IGF-2 delivery to muscles of SOD1(G93A) ALS mice extended life-span by 10%, while preserving motor neurons and inducing motor axon regeneration.
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27180807 |
2016 |
rs35767
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Diabetes Mellitus, Non-Insulin-Dependent
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0.050 |
GeneticVariation
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BEFREE |
The SNP rs7754840 in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for T2DM in Uyghurs.
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25785549 |
2015 |
rs35767
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Diabetes Mellitus, Non-Insulin-Dependent
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0.050 |
GeneticVariation
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BEFREE |
AG genotype of rs6218 and TT genotype of rs35767 were significantly associated with the elevated risk of DR (rs6218: OR=1.77, <i>P</i>=0.04; rs35767: OR=2.32, <i>P</i>=0.03) and type II diabetes mellitus (T2DM) (rs6218: OR=1.92, <i>P</i>=0.00. rs35767: OR=2.29, <i>P</i>=0.02).
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29152139 |
2017 |
rs35767
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Diabetes Mellitus, Non-Insulin-Dependent
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0.050 |
GeneticVariation
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BEFREE |
We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively).
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22992776 |
2012 |
rs35767
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Diabetes Mellitus, Non-Insulin-Dependent
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0.050 |
GeneticVariation
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BEFREE |
We considered type 2 diabetes mellitus as a model and identified a well-known diabetic risk variant rs35767 using iTEA.
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29440655 |
2018 |
rs35767
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Diabetes Mellitus, Non-Insulin-Dependent
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0.050 |
GeneticVariation
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BEFREE |
The rs35767 polymorphism was not associated with age, gender, BMI, waist circumference, smoking, blood pressure, plasma glucose, HbA1c, type 2 diabetes, HOMA-IR, hsCRP, eGFR, and lipid profile.
|
28415730 |
2017 |
rs6214
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Severe myopia
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0.040 |
GeneticVariation
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BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
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26076017 |
2015 |
rs6214
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Severe myopia
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0.040 |
GeneticVariation
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BEFREE |
To determine the distribution of the HM-associated SNPs rs6214 and rs10860860, 543 unrelated individuals from the general Polish population were also analyzed.
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21976954 |
2011 |
rs6214
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Severe myopia
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0.040 |
GeneticVariation
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BEFREE |
This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia.
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28135889 |
2017 |
rs6214
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Severe myopia
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0.040 |
GeneticVariation
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BEFREE |
We found a significant association of the IGF-1 gene rs6214 polymorphism in Egyptian patients with simple myopia and high-grade myopia.
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27167306 |
2016 |
rs35767
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Osteoporosis
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0.040 |
GeneticVariation
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BEFREE |
Our study found that CT+TT genotype of rs35767 was significantly associated with moderate increased risk of osteo</span>porosis in smokers and drinkers, and the ORs (95% CI) were 2.11 (1.06-4.20) and 2.36 (1.29-4.32), respectively.
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26191288 |
2015 |
rs35767
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Osteoporosis
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0.040 |
GeneticVariation
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BEFREE |
According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97).
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26214445 |
2015 |
rs35767
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Osteoporosis
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0.040 |
GeneticVariation
|
BEFREE |
Taken together, the findings of our current study suggested a significant association between rs35767 polymorphism and risk of osteoporosis in Chinese post-menopausal women.
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29747606 |
2018 |
rs35767
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Osteoporosis
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0.040 |
GeneticVariation
|
BEFREE |
Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population.
|
26600491 |
2015 |
rs745410279
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Noonan-Like Syndrome With Loose Anagen Hair
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0.030 |
GeneticVariation
|
BEFREE |
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721), recently related to the invariant c.4A>G missense change in SHOC2, is characterized by features reminiscent of Noonan syndrome.
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22419608 |
2012 |