|
rs1239905891
|
|
Mammary Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs1239905891
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs1239905891
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs12423791
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs of the IGF1R (rs12423791), and IGF1 (rs2162679, rs5742612, rs35767) genes were significantly associated with tumor response to FOLFOX.
|
27144430 |
2016 |
|
rs12423791
|
|
Severe myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
|
26076017 |
2015 |
|
rs12423791
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the sum of the risk genetic factors in each LD block (19-repeat allele, C allele of rs12423791, or C-T haplotype) was considered, patients with all the risk factors had significantly shorter cancer specific-survival than those with 0-2 risk factors (P = 0.0003).
|
23530598 |
2013 |
|
rs12423791
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the sum of the risk genetic factors in each LD block (19-repeat allele, C allele of rs12423791, or C-T haplotype) was considered, patients with all the risk factors had significantly shorter cancer specific-survival than those with 0-2 risk factors (P = 0.0003).
|
23530598 |
2013 |
|
rs12423791
|
|
Myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population and should be investigated further.
|
22509095 |
2012 |
|
rs1520220
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer.
|
30111277 |
2018 |
|
rs1520220
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis demonstrate that the role of IGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations.
|
30111277 |
2018 |
|
rs1520220
|
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the rs1520220 and rs2195239 variants were correlated with M1 and E1 in patients with IgAN (M0/M1: CC vs. CG+GG: OR = 1.62, P = 0.04; E0/E1: CC vs. CG+GG: OR = 1.95, P = 0.004; GG vs. GC+CC: OR = 1.90, P = 0.004, respectively).
|
29402846 |
2018 |
|
rs1520220
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of our meta-analysis demonstrate that the role of IGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations.
|
30111277 |
2018 |
|
rs1520220
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer.
|
30111277 |
2018 |
|
rs1520220
|
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate Cox model (adjusted for age, gender, histology, pathological stage, adjuvant chemotherapy, and history of diabetes), two IGF-I polymorphisms, rs1520220 and rs2195239, were significantly associated with RFS (hazard ratio [HR] 0.60, 95% CI 0.40-0.91; and HR 0.60, 95% CI 0.41-0.89, respectively, in a per-allele model).
|
21690232 |
2012 |
|
rs1520220
|
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate Cox model (adjusted for age, gender, histology, pathological stage, adjuvant chemotherapy, and history of diabetes), two IGF-I polymorphisms, rs1520220 and rs2195239, were significantly associated with RFS (hazard ratio [HR] 0.60, 95% CI 0.40-0.91; and HR 0.60, 95% CI 0.41-0.89, respectively, in a per-allele model).
|
21690232 |
2012 |
|
rs1520220
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that the C allele in rs1520220 and the G allele in rs4764887 were significantly associated with stomach cancer risk in the per-allele model after adjusting for other risk factors (OR: 1.14 [95% CI: 1.00-1.30] and OR: 1.18 [95% CI: 1.02-1.36], respectively).
|
21854509 |
2011 |
|
rs1520220
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that the C allele in rs1520220 and the G allele in rs4764887 were significantly associated with stomach cancer risk in the per-allele model after adjusting for other risk factors (OR: 1.14 [95% CI: 1.00-1.30] and OR: 1.18 [95% CI: 1.02-1.36], respectively).
|
21854509 |
2011 |
|
rs2072592
|
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The logistic regression analysis revealed that the GG + AG variant of rs2162679 (P = 0.047), the AA + GA variant of rs2072592 (P = 0.005) and the CC + TC variant of rs6218 (P = 0.015) exhibited a protective effect for CI in the total subject group.
|
23121326 |
2012 |
|
rs2072592
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotype-based case-control study revealed that the frequency of the A-T-G-G haplotype for rs2162679-rs7956547-rs2072592-rs978458 was significantly higher in the MI group (47.3%) as compared to the non-MI group (41.4%) (p=0.037, odds ratio=1.270).
|
21039458 |
2010 |
|
rs2162679
|
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2162679
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2162679
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
IGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
|
30654740 |
2019 |
|
rs2162679
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
IGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
|
30654740 |
2019 |
|
rs2162679
|
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The logistic regression analysis revealed that the GG + AG variant of rs2162679 (P = 0.047), the AA + GA variant of rs2072592 (P = 0.005) and the CC + TC variant of rs6218 (P = 0.015) exhibited a protective effect for CI in the total subject group.
|
23121326 |
2012 |
|
rs2162679
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of the A-T-G-T haplotype for rs2162679-rs7956547-rs978458-rs6218 was also significantly higher in the MI group (47.3%) as compared to the non-MI group (41.3%) (p=0.033, odds ratio=1.276).
|
21039458 |
2010 |