|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall results suggest changes in neuromodulator levels are subtle in SOD1-G93A ALS mixed cell cultures.
|
30618638 |
2018 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, the aim of this study was to investigate the effect of intravenous delivery of human IGF1 by self-complementary adeno-associated virus (scAAV) vectors in 90-day-old SOD1-G93A ALS mice.
|
29499331 |
2018 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Intraspinal administration of human spinal cord-derived neural progenitor cells in the G93A-SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors.
|
25641599 |
2017 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Finally, AAV9::IGF-2 delivery to muscles of SOD1(G93A) ALS mice extended life-span by 10%, while preserving motor neurons and inducing motor axon regeneration.
|
27180807 |
2016 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS.
|
22523565 |
2012 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report that symptomatic male hSOD1(G93A) transgenic mice exhibit a deficiency in GH secretion similar to that seen in human ALS.
|
22621959 |
2012 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we investigate the influence of the soluble factors released by hADSCs on the GLT1 in primary astrocytes cultured from SOD1(G93A) mice, a widely studied mutant human SOD1 transgenic model of ALS.
|
20152807 |
2010 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results.
|
19038252 |
2009 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis (ALS), we transplanted hNPs or growth factor (GF)-expressing hNPs into the central nervous system (CNS) of mutant Cu/Zn superoxide dismutase (SOD1(G93A)) transgenic mice.
|
19322031 |
2009 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Innate and adaptive immunity were investigated in the CNS of the Superoxide Dismutase 1 (SOD1)(G93A) transgenic mouse model of ALS.
|
18997009 |
2008 |
|
rs745805222
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the effect of specific and sustained IGF-1 expression in skeletal muscle or central nervous system on motor performance, life span, and motor neuron survival, human-IGF-1 transgenic mice were crossed with the G93A SOD-1 mutant model of ALS.
|
17597610 |
2007 |
|
rs35767
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
We considered type 2 diabetes mellitus as a model and identified a well-known diabetic risk variant rs35767 using iTEA.
|
29440655 |
2018 |
|
rs35767
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
AG genotype of rs6218 and TT genotype of rs35767 were significantly associated with the elevated risk of DR (rs6218: OR=1.77, <i>P</i>=0.04; rs35767: OR=2.32, <i>P</i>=0.03) and type II diabetes mellitus (T2DM) (rs6218: OR=1.92, <i>P</i>=0.00. rs35767: OR=2.29, <i>P</i>=0.02).
|
29152139 |
2017 |
|
rs35767
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
The rs35767 polymorphism was not associated with age, gender, BMI, waist circumference, smoking, blood pressure, plasma glucose, HbA1c, type 2 diabetes, HOMA-IR, hsCRP, eGFR, and lipid profile.
|
28415730 |
2017 |
|
rs35767
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
The SNP rs7754840 in CDKAL1, rs864745 in JAZF1, and rs35767 in IGF1 might serve as potential susceptibility loci for T2DM in Uyghurs.
|
25785549 |
2015 |
|
rs35767
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively).
|
22992776 |
2012 |
|
rs35767
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Taken together, the findings of our current study suggested a significant association between rs35767 polymorphism and risk of osteoporosis in Chinese post-menopausal women.
|
29747606 |
2018 |
|
rs35767
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study found that CT+TT genotype of rs35767 was significantly associated with moderate increased risk of osteo</span>porosis in smokers and drinkers, and the ORs (95% CI) were 2.11 (1.06-4.20) and 2.36 (1.29-4.32), respectively.
|
26191288 |
2015 |
|
rs35767
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97).
|
26214445 |
2015 |
|
rs35767
|
|
Osteoporosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population.
|
26600491 |
2015 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia.
|
28135889 |
2017 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found a significant association of the IGF-1 gene rs6214 polymorphism in Egyptian patients with simple myopia and high-grade myopia.
|
27167306 |
2016 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
|
26076017 |
2015 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
To determine the distribution of the HM-associated SNPs rs6214 and rs10860860, 543 unrelated individuals from the general Polish population were also analyzed.
|
21976954 |
2011 |
|
rs6214
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction.
|
24608110 |
2014 |