|
rs760761240
|
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively.
|
17700210 |
2007 |
|
rs4586
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate the possible association between polymorphisms [the -2510A/G promoter polymorphism (rs1024611) and the Cys35Cys coding polymorphism (rs4586) in exon 2] of the chemokine (C-C motif) ligand 2 (CCL2) gene and knee osteoarthritis (OA) in a Korean population.
|
17763208 |
2007 |
|
rs2857656
|
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MCP-1 rs2857656 CC genotype is independently associated with carotid artery plaque in African American from families with premature coronary artery disease.
|
19506371 |
2009 |
|
rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity.
|
21346327 |
2011 |
|
rs3760396
|
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results showed that variant genotypes of CCL2 rs3760396 and CCL8 rs3138035 were associated with a significantly decreased risk of death for NSCLC (dominant model: adjusted HR=0.65, 95% CI=0.48-0.89 for rs3760396; dominant model: adjusted HR=0.65, 95% CI=0.49-0.86 for rs3138035), while CXCL12 rs1804429 was associated with an increased risk of death for NSCLC (CC vs AA: adjusted HR=6.03, 95% CI=1.44-25.24).
|
21514686 |
2011 |
|
rs4586
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children.
|
21556333 |
2011 |
|
rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Using an ALS mouse model carrying a high copy number of a mutant human superoxide dismutase-1 (SOD1)(G93A) transgene, we investigated the effect of neural induction on the innate therapeutic potential of mesenchymal stem cells (MSCs) in relation to preclinical transplantation parameters.
|
22472631 |
2013 |
|
rs3917887
|
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs3917887
|
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs3917887
|
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs4586
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
rs4586
|
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
rs3760396
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is a pilot study analysing association of chemokine gene polymorphisms (CXCL1, rs3117604; CXCL2, rs3806792; CCL2, rs2857656 and rs3760396; CCL5, rs2107538) in Korean patients with ischemic stroke (IS) (n = 120) and age-matched controls (n = 267).
|
23198952 |
2013 |
|
rs2857657
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls.
|
23211090 |
2013 |
|
rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
|
23752092 |
2013 |
|
rs4586
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
The binary logistic regression model is an appropriate tool to predict AMD in the presence of serum CFH, serum CCL2, serum SOD1, polymorphism in CCL2 (rs4586), stress, and comorbidity with high specificity and sensitivity.
|
23848218 |
2013 |
|
rs2857656
|
|
Tuberculosis, Spinal
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MCP-1-362G/C (rs2857656) polymorphism and blood levels of MCP-1 in patients with spinal TB and healthy subjects were evaluated and compared.
|
24183600 |
2014 |
|
rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
|
24820540 |
2014 |
|
rs3917887
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |
|
rs3917887
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |
|
rs3917887
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs3917887
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs3760396
|
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs3760396
|
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs3760396
|
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |