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rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
|
24820540 |
2014 |
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rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Using an ALS mouse model carrying a high copy number of a mutant human superoxide dismutase-1 (SOD1)(G93A) transgene, we investigated the effect of neural induction on the innate therapeutic potential of mesenchymal stem cells (MSCs) in relation to preclinical transplantation parameters.
|
22472631 |
2013 |
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rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
|
23752092 |
2013 |
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rs746076530
|
|
Amyotrophic Lateral Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity.
|
21346327 |
2011 |
|
rs4586
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
The binary logistic regression model is an appropriate tool to predict AMD in the presence of serum CFH, serum CCL2, serum SOD1, polymorphism in CCL2 (rs4586), stress, and comorbidity with high specificity and sensitivity.
|
23848218 |
2013 |
|
rs4586
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology.
|
29664944 |
2018 |
|
rs3760396
|
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner.
|
27145753 |
2016 |
|
rs3760396
|
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results showed that variant genotypes of CCL2 rs3760396 and CCL8 rs3138035 were associated with a significantly decreased risk of death for NSCLC (dominant model: adjusted HR=0.65, 95% CI=0.48-0.89 for rs3760396; dominant model: adjusted HR=0.65, 95% CI=0.49-0.86 for rs3138035), while CXCL12 rs1804429 was associated with an increased risk of death for NSCLC (CC vs AA: adjusted HR=6.03, 95% CI=1.44-25.24).
|
21514686 |
2011 |
|
rs2857656
|
|
Tuberculosis, Spinal
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03).
|
26626202 |
2016 |
|
rs2857656
|
|
Tuberculosis, Spinal
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MCP-1-362G/C (rs2857656) polymorphism and blood levels of MCP-1 in patients with spinal TB and healthy subjects were evaluated and compared.
|
24183600 |
2014 |
|
rs760761240
|
|
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively.
|
17700210 |
2007 |
|
rs4586
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 14 SNPs, CCL2 rs4586 and PDCD1 rs10204525 were found to have an influence on the survival outcomes of the patients with resectable CRC.
|
27339628 |
2016 |
|
rs4586
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
rs4586
|
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children.
|
21556333 |
2011 |
|
rs4586
|
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
rs4586
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate the possible association between polymorphisms [the -2510A/G promoter polymorphism (rs1024611) and the Cys35Cys coding polymorphism (rs4586) in exon 2] of the chemokine (C-C motif) ligand 2 (CCL2) gene and knee osteoarthritis (OA) in a Korean population.
|
17763208 |
2007 |
|
rs4586
|
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, CCL2 gene polymorphisms (rs1024611 and rs4586) confer susceptibility to OA and may be potential markers for early diagnosis of OA.
|
31495394 |
2019 |
|
rs4586
|
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
GDM was significantly associated with genotypes and alleles of the <i>CCL2</i> rs1024611 and rs4586 polymorphisms, while there was no statistically significant association between the <i>CCL5</i> rs2107538, <i>IL4</i> rs2243250, <i>IL15</i> rs2857261, and rs2254514 gene polymorphisms and GDM.
|
27472286 |
2017 |
|
rs3917887
|
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs3917887
|
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs3917887
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |
|
rs3917887
|
|
Tuberculosis, Spinal
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03).
|
26626202 |
2016 |
|
rs3917887
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs3917887
|
|
Malignant neoplasm of urinary bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |
|
rs3917887
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |