|
rs13900
|
|
Leishmaniasis, Cutaneous
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms in regulatory regions of the <i>CCL2</i> promoter were analyzed in a pilot cohort of DNA samples from CL patients (cures n=20 and treatment failure n=20), showing putative association of rs13900(C/T) and rs2857656(G/C) with treatment outcome.
|
31818959 |
2020 |
|
rs13900
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5.
|
30175654 |
2019 |
|
rs2857656
|
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development.
|
28472164 |
2017 |
|
rs2857656
|
|
Severe Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1024611 AG/GG and rs2857656 GC/CC genotypes were both overrepresented in patients with severe sepsis (both P = 0.0005) and septic shock (P = 0.010 and P = 0.015, respectively) compared to the patients with mild sepsis.
|
28472164 |
2017 |
|
rs2857656
|
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development.
|
28472164 |
2017 |
|
rs2857656
|
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MCP-1 rs2857656 CC genotype is independently associated with carotid artery plaque in African American from families with premature coronary artery disease.
|
19506371 |
2009 |
|
rs2857657
|
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls.
|
23211090 |
2013 |
|
rs3760396
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner.
|
27145753 |
2016 |
|
rs3760396
|
|
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031).
|
27145753 |
2016 |
|
rs3760396
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner.
|
27145753 |
2016 |
|
rs3760396
|
|
Adenosquamous carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031).
|
27145753 |
2016 |
|
rs3760396
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner.
|
27145753 |
2016 |
|
rs3760396
|
|
Adenosquamous cell lung cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, minor allele G of rs3760396 polymorphism was significantly associated with increased risk of adenosquamous lung carcinoma with either allelic genetic model (OR = 5.29, P < 0.001), or dominant genetic model (OR = 9.88, P < 0.001), or genotypic model (GC genotype vs. CC genotype, OR = 10.73, P < 0.001).
|
27145753 |
2016 |
|
rs3760396
|
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs3760396
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients.
|
26277553 |
2015 |
|
rs3760396
|
|
ovarian neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs3760396
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients.
|
26277553 |
2015 |
|
rs3760396
|
|
Malignant neoplasm of ovary
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
|
25289731 |
2015 |
|
rs3760396
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
This is a pilot study analysing association of chemokine gene polymorphisms (CXCL1, rs3117604; CXCL2, rs3806792; CCL2, rs2857656 and rs3760396; CCL5, rs2107538) in Korean patients with ischemic stroke (IS) (n = 120) and age-matched controls (n = 267).
|
23198952 |
2013 |
|
rs3917887
|
|
Tuberculosis, Spinal
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03).
|
26626202 |
2016 |
|
rs3917887
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |
|
rs3917887
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for prostate cancer (PCa) risk.
|
25266801 |
2015 |
|
rs3917887
|
|
Kidney Failure, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs3917887
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs3917887
|
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested association of three gene polymorphisms of CCL2I/D (rs3917887), CCL2A2518G (rs1024611) and CCR2V64I (rs1799864) with BC risk in North Indian population.
|
22733495 |
2012 |