Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10168266
rs10168266
STAT4
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		T 0.800 GeneticVariation GWASDB A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066

2013
dbSNP: rs7601754
rs7601754
STAT4
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.800 GeneticVariation GWASDB A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 23740937

2013
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		T 0.900 GeneticVariation GWASDB Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. 18204098

2008
dbSNP: rs3024921
rs3024921
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.800 GeneticVariation GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000

2012
dbSNP: rs6715106
rs6715106
STAT4
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.800 GeneticVariation GWASDB Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. 22057235

2011
dbSNP: rs10174238
rs10174238
STAT4
CUI: C3898105
Disease: Oligoarticular Juvenile Idiopathic Arthritis
Oligoarticular Juvenile Idiopathic Arthritis 		0.800 GeneticVariation GWASDB Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761

2013
dbSNP: rs3821236
rs3821236
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.810 GeneticVariation GWASDB Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 21408207

2011
dbSNP: rs1517352
rs1517352
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation GWASDB Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 21408207

2011
dbSNP: rs10931481
rs10931481
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation GWASDB Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 21408207

2011
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		T 0.900 GeneticVariation GWASDB For example, rs7574865 in STAT4 had an OR for anti-dsDNA + SLE of 1.77 (95% CI 1.57-1.99, p = 2.0E-20) compared to an OR for anti-dsDNA - SLE of 1.26 (95% CI 1.12-1.41, p = 2.4E-04), with p(heterogeneity)<0.0005. 21408207

2011
dbSNP: rs10168266
rs10168266
STAT4
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.700 GeneticVariation GWASDB Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese. 23028356

2012
dbSNP: rs3821236
rs3821236
STAT4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.700 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs3024921
rs3024921
STAT4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.700 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs1517352
rs1517352
STAT4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.700 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs10931481
rs10931481
STAT4
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.700 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013
dbSNP: rs3821236
rs3821236
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.810 GeneticVariation GWASDB Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. 19165918

2008
dbSNP: rs11889341
rs11889341
STAT4
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		T 0.800 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014
dbSNP: rs7574070
rs7574070
STAT4
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		A 0.810 GeneticVariation GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587

2013
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.900 GeneticVariation GWASDB Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. 18204446

2008
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		T 0.810 GeneticVariation GWASDB Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. 23000144

2012
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		A 0.900 GeneticVariation GWASDB Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193

2009
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		T 0.900 GeneticVariation GWASDB Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842

2010
dbSNP: rs3821236
rs3821236
STAT4
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		A 0.800 GeneticVariation GWASDB Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147

2010
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364

2011
dbSNP: rs7574865
rs7574865
STAT4
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		T 0.900 GeneticVariation GWASDB Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. 23053960

2012