|
rs4733220
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, in MDR, the gene-gene interaction among the five SNPs (WRN-rs4733220 (G>A), WRN-rs1801195 (T>G), OGG1-rs2072668 (G>C) and OGG1-rs2304277 (A>G)) on ARC risk was significant (OR = 5.03, 95% CI: 3.54~7.13).
|
29689049 |
2018 |
|
rs4733220
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs13181
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the CC genotype of XPD Lys751Gln (A/C) SNP seemed to portend a decreased risk for ARC in Caucasian populations but not in Asian populations.
|
24906341 |
2014 |
|
rs13181
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to find out a correlation, if any, between ARC and the single nucleotide polymorphisms (SNPs) in DNA repair genes XRCC1 (X-ray repair cross-complementary-1) [Arg194Trp (rs1799782)] and XPD (xerodermapigmentosa complementation group D) [Lys751Gln (rs13,181].
|
28560653 |
2018 |
|
rs11574311
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on single-locus analyses of the 18 SNPs examined, WRN-rs11574311 (T>C) was associated with ARC risk.
|
29689049 |
2018 |
|
rs11574311
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs1063147
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown that BLM-rs1063147 is initially associated with nuclear ARC in a cross-section study.
|
30227115 |
2019 |
|
rs1063147
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Regarding the OGG1-rs1052133, the GG (OR = 1.925; 95%CI, 1.181-3.136; p = 0.009) and CG (OR = 1.384; 95%CI, 1.171-1.636; p<0.001) genotypes indicated higher risk of ARC.
|
28253266 |
2017 |
|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The OGG1 gene Ser326Cys polymorphism was associated with ARC risk.
|
28631182 |
2018 |
|
rs9651118
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed an adverse effect of the haplotype "C-A-T-C" (alleles in order of SNPs rs3737967, rs1801131, rs1801133 and rs9651118) on ARC risk (OR = 1.55, P = 0.003).
|
26689687 |
2015 |
|
rs759412116
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele and GA genotype of XRCC1 Arg399Gln (G/A) SNP might increase risk for ARC in Asian populations but not in Caucasian populations.
|
24906341 |
2014 |
|
rs7548209
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significantly higher frequencies of the GG genotype and the G allele of rs7548209 were observed in ARC patients compared with controls (χ(2)=10.430, pc=0.015, OR 1.660, 95% CI 1.219 to 2.261 and χ(2)=8.537, pc=0.015, OR 1.486, 95% CI 1.138 to 1.940, respectively).
|
21686326 |
2011 |
|
rs7541950
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, three GJA8-tagged single nucleotide polymorphisms related to an increased ARC risk were identified: rs2132397 for general ARC under both dominant and additive models; rs7541950 for general ARC under both recessive and additive models; and rs6657114 for cortical cataract under the recessive model.
|
30349978 |
2018 |
|
rs74641138
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicate that the genotype TC in polymorphism c.-4T>C and haplotype CCG of rs2269348, c.-4T>C, and rs74641138 in MIP may attach an additional genetic risk factor for ARC in Chinese.
|
21921980 |
2011 |
|
rs7278468
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Thus, our data suggest that the T allele of rs7278468 in the CRYAA promoter is associated with ARC through increasing binding of KLF-10 and thus decreasing CRYAA transcription.
|
26984531 |
2016 |
|
rs7154572
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the haplotypic analysis, the haplotypes consisting of rs7154572, rs7150141 and rs12432994 in Kinesin Light Chain 1 Gene (KLC1) showed significant association with ARC (p = 0.000878).
|
23776437 |
2013 |
|
rs7150141
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the haplotypic analysis, the haplotypes consisting of rs7154572, rs7150141 and rs12432994 in Kinesin Light Chain 1 Gene (KLC1) showed significant association with ARC (p = 0.000878).
|
23776437 |
2013 |
|
rs6657114
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, three GJA8-tagged single nucleotide polymorphisms related to an increased ARC risk were identified: rs2132397 for general ARC under both dominant and additive models; rs7541950 for general ARC under both recessive and additive models; and rs6657114 for cortical cataract under the recessive model.
|
30349978 |
2018 |
|
rs5881286
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype association including the - allele of rs5881286, C allele of rs2242318, and A allele of rs144581330 exhibited significantly higher distribution in the patients with ARC (p=8.0e-4; OR=3.38; 95% CI=1.66-6.87).
|
23882136 |
2013 |
|
rs477558
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of the rs477558 AG genotype was significantly decreased in ARC patients compared with controls (χ(2)=9.281, pc=0.030, OR 0.626, 95% CI 0.463 to 0.847).
|
21686326 |
2011 |
|
rs4639
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals carrying different rs4639 alleles had distinct <i>NEIL2</i> expression in lens capsule tissues from ARC cases and controls.
|
31253066 |
2019 |
|
rs4585
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggested that the SNP rs4585 in <i>ATM</i> might affect ARC risk through modulating the regulatory affinity of miR-2964a-5p.
|
29156695 |
2017 |
|
rs3761382
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs nominally associated with ARC were identified in the promoter region of CRYAA: rs3761382 (P = 0.06, OR (Odds ratio) = 1.5), rs13053109 (P = 0.04, OR = 1.6), rs7278468 (P = 0.007, OR = 0.6).
|
26984531 |
2016 |
|
rs2725383
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |