|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The OGG1 gene Ser326Cys polymorphism was associated with ARC risk.
|
28631182 |
2018 |
|
rs1052133
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Regarding the OGG1-rs1052133, the GG (OR = 1.925; 95%CI, 1.181-3.136; p = 0.009) and CG (OR = 1.384; 95%CI, 1.171-1.636; p<0.001) genotypes indicated higher risk of ARC.
|
28253266 |
2017 |
|
rs1063147
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have recently shown that BLM-rs1063147 is initially associated with nuclear ARC in a cross-section study.
|
30227115 |
2019 |
|
rs1063147
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs11574311
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on single-locus analyses of the 18 SNPs examined, WRN-rs11574311 (T>C) was associated with ARC risk.
|
29689049 |
2018 |
|
rs11574311
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs13181
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to find out a correlation, if any, between ARC and the single nucleotide polymorphisms (SNPs) in DNA repair genes XRCC1 (X-ray repair cross-complementary-1) [Arg194Trp (rs1799782)] and XPD (xerodermapigmentosa complementation group D) [Lys751Gln (rs13,181].
|
28560653 |
2018 |
|
rs13181
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that the CC genotype of XPD Lys751Gln (A/C) SNP seemed to portend a decreased risk for ARC in Caucasian populations but not in Asian populations.
|
24906341 |
2014 |
|
rs4733220
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, in MDR, the gene-gene interaction among the five SNPs (WRN-rs4733220 (G>A), WRN-rs1801195 (T>G), OGG1-rs2072668 (G>C) and OGG1-rs2304277 (A>G)) on ARC risk was significant (OR = 5.03, 95% CI: 3.54~7.13).
|
29689049 |
2018 |
|
rs4733220
|
|
AIDS related complex
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results show that WRN-rs11574311 was initially associated with ARC in general, cortical, and mixed cataracts (P = 0.003, odds ratio [OR] = 1.49; P = 0.001, OR = 1.68; and P < 0.0001, OR = 2.08), BLM-rs1063147 with nuclear cataract (P = 0.03, OR = 1.31), WRN-rs2725383 with cortical cataract (P = 0.01, OR = 1.49), and WRN-rs4733220 and WRN-rs2725338 with mixed cataract (P = 0.04, OR = 0.74; P = 0.003, OR = 0.60).
|
23322570 |
2013 |
|
rs10981985
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study suggests that the rs10981985 G → A variant within the TDRD7 gene may protect against cortical ARC in a Han Chinese population.
|
24435515 |
2014 |
|
rs1136410
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study suggests that SNP rs1136410 may confer susceptibility to ARC by affecting PARP activities and oxidative DNA damage.
|
27840165 |
2017 |
|
rs12432994
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the haplotypic analysis, the haplotypes consisting of rs7154572, rs7150141 and rs12432994 in Kinesin Light Chain 1 Gene (KLC1) showed significant association with ARC (p = 0.000878).
|
23776437 |
2013 |
|
rs13053109
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three SNPs nominally associated with ARC were identified in the promoter region of CRYAA: rs3761382 (P = 0.06, OR (Odds ratio) = 1.5), rs13053109 (P = 0.04, OR = 1.6), rs7278468 (P = 0.007, OR = 0.6).
|
26984531 |
2016 |
|
rs1346044
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
We concluded that the C allele of rs1346044, a non-synonymous SNP resulting in the conversion of Cys to Arg at amino acid position 1367 of WRN, alters susceptibility to ARC, especially the cortical type of the disease, in the Han Chinese.
|
23334603 |
2013 |
|
rs144581330
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype association including the - allele of rs5881286, C allele of rs2242318, and A allele of rs144581330 exhibited significantly higher distribution in the patients with ARC (p=8.0e-4; OR=3.38; 95% CI=1.66-6.87).
|
23882136 |
2013 |
|
rs1799782
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicated that both SNPs Arg194Trp in XRCC1 (P = 0.967) and Lys751Gln in XPD (P = 0.995) were not associated with ARC whether they were analyzed individually or in combined form (P > 0.05).
|
28560653 |
2018 |
|
rs1801131
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed an adverse effect of the haplotype "C-A-T-C" (alleles in order of SNPs rs3737967, rs1801131, rs1801133 and rs9651118) on ARC risk (OR = 1.55, P = 0.003).
|
26689687 |
2015 |
|
rs1801133
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed an adverse effect of the haplotype "C-A-T-C" (alleles in order of SNPs rs3737967, rs1801131, rs1801133 and rs9651118) on ARC risk (OR = 1.55, P = 0.003).
|
26689687 |
2015 |
|
rs1801195
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in MDR, the gene-gene interaction among the five SNPs (WRN-rs4733220 (G>A), WRN-rs1801195 (T>G), OGG1-rs2072668 (G>C) and OGG1-rs2304277 (A>G)) on ARC risk was significant (OR = 5.03, 95% CI: 3.54~7.13).
|
29689049 |
2018 |
|
rs199980747
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genetic variations c.668C>T (rs201008479), c.102C>T (rs199980747) and c.-27C>G (rs200187971) may present an additional genetic risk factor for ARC in the Chinese population.
|
25300504 |
2014 |
|
rs200187971
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genetic variations c.668C>T (rs201008479), c.102C>T (rs199980747) and c.-27C>G (rs200187971) may present an additional genetic risk factor for ARC in the Chinese population.
|
25300504 |
2014 |
|
rs201008479
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genetic variations c.668C>T (rs201008479), c.102C>T (rs199980747) and c.-27C>G (rs200187971) may present an additional genetic risk factor for ARC in the Chinese population.
|
25300504 |
2014 |
|
rs2057768
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Less eczema was seen in individuals with the AA-genotype of rs2057768, and less ARC among those with the AA-genotype of rs2107356, especially ARC associated with sensitization to pollen.
|
20002627 |
2010 |
|
rs2072668
|
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, in MDR, the gene-gene interaction among the five SNPs (WRN-rs4733220 (G>A), WRN-rs1801195 (T>G), OGG1-rs2072668 (G>C) and OGG1-rs2304277 (A>G)) on ARC risk was significant (OR = 5.03, 95% CI: 3.54~7.13).
|
29689049 |
2018 |