|
rs2910164
|
|
Papillary thyroid carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In an association study of 608 PTC patients and 901 controls, we found marked differences in genotype distribution of rs2910164 (P = 0.000002), the GC heterozygous state being associated with an increased risk of acquiring PTC (odds ratio = 1.62, P = 0.000007), and both homozygous states protective with odds ratio = 0.42 for the CC genotype (P = 0.003) and odds ratio = 0.69 for the GG genotype (P = 0.0006).
|
18474871 |
2008 |
|
rs2910164
|
|
Malignant neoplasm of ovary
|
|
0.020 |
GeneticVariation
|
BEFREE |
To examine whether rs2910164 plays any role in breast and/or ovarian cancer, we studied associations between this polymorphism and age of diagnosis in 42 patients with familial breast cancer and 82 patients with familial ovarian cancer.
|
18660546 |
2008 |
|
rs2910164
|
|
ovarian neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
To examine whether rs2910164 plays any role in breast and/or ovarian cancer, we studied associations between this polymorphism and age of diagnosis in 42 patients with familial breast cancer and 82 patients with familial ovarian cancer.
|
18660546 |
2008 |
|
rs2910164
|
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
To examine whether rs2910164 plays any role in breast and/or ovarian cancer, we studied associations between this polymorphism and age of diagnosis in 42 patients with familial breast cancer and 82 patients with familial ovarian cancer.
|
18660546 |
2008 |
|
rs2910164
|
|
Coronary heart disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
We conducted a three-stage case-control study of CHD in Chinese to test our hypothesis by genotyping miR-196a2 rs11614913 and three other pre-miRNA SNPs (miR-146a rs2910164, miR-149 rs2292832, and miR-499 rs3746444) in 1,324 CHD cases and 1,783 non-CHD controls.
|
19514064 |
2009 |
|
rs2910164
|
|
trachomatis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether the SNPs miR-146a G>C (rs2910164), NLRP3 C>T (rs4925663) and G>A (rs12065526) are associated with the susceptibility to and severity of C. trachomatis infection.
|
20011700 |
2009 |
|
rs2910164
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients.
|
20810544 |
2010 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients.
|
20810544 |
2010 |
|
rs2910164
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 (G>C) SNP in the miR-146a is associated with susceptibility to GC.
|
21073609 |
2010 |
|
rs2910164
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 CC genotype held a significantly higher risk of GC when compared to non-cancer subjects (adjusted odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.02-1.66, p =.03).
|
21073609 |
2010 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis.
|
19847796 |
2010 |
|
rs2910164
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to reveal if there is any association of miRNA-146a variant rs2910164 and the two interleukin (IL) 1 receptor associated kinase (IRAK1, a target gene of mir-146a) polymorphisms rs3027898 and rs1059703 with RA predisposition.
|
20870441 |
2010 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis.
|
19847796 |
2010 |
|
rs2910164
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 (G>C) SNP in the miR-146a is associated with susceptibility to GC.
|
21073609 |
2010 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 CC genotype held a significantly higher risk of GC when compared to non-cancer subjects (adjusted odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.02-1.66, p =.03).
|
21073609 |
2010 |
|
rs2910164
|
|
Malignant neoplasm of prostate
|
|
0.050 |
GeneticVariation
|
BEFREE |
To explore whether rs2910164 plays any role in prostate cancer (CaP), we analyzed the association between miR-146a polymorphism and risk of CaP and the expression of miR-146a with different genotypes in CaP tissues in southern Chinese Han population.
|
19902466 |
2010 |
|
rs2910164
|
|
Prostate carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
To explore whether rs2910164 plays any role in prostate cancer (CaP), we analyzed the association between miR-146a polymorphism and risk of CaP and the expression of miR-146a with different genotypes in CaP tissues in southern Chinese Han population.
|
19902466 |
2010 |
|
rs2910164
|
|
Squamous cell carcinoma of the head and neck
|
|
0.050 |
GeneticVariation
|
BEFREE |
The authors genotyped 4 common polymorphisms in pre-miRNAs: Homo sapiens miRNA 146a (hsa-mir-146a) (reference SNP 2910164 [rs2910164]; guanine to cytosine [G→C]), hsa-mir-149 (rs2292832; guanine to thymine [G→T]), hsa-mir-196a2 (rs11614913; C→T), and hsa-mir-499 (rs3746444; adenine to guanine [A→G]) in 1109 patients with SCCHN (cases) and in 1130 cancer-free patients (controls) in a non-Hispanic white population that was frequency-matched by age and sex.
|
20549817 |
2010 |
|
rs2910164
|
|
Squamous cell carcinoma of esophagus
|
|
0.040 |
GeneticVariation
|
BEFREE |
Compared with rs2910164 variant genotype CC, genotype GG was associated with increased risk of ESCC (Odds Ratio, 2.39, 95% Confidence Interval, 1.36-4.20).
|
20680470 |
2010 |
|
rs2910164
|
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.020 |
GeneticVariation
|
BEFREE |
We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis in Japanese population.
|
21073609 |
2010 |
|
rs2910164
|
|
Cardiomyopathy, Familial Idiopathic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both the has-mir-196a2 rs11614913 C/T and hsa-mir-499 rs3746444 A/G, but not hsa-mir-146a rs2910164 C/G, are associated with a significantly increased risk of DCM, indicating that common genetic polymorphisms in pre-microRNAs are associated with DCM.
|
20488170 |
2010 |
|
rs2910164
|
|
Stage IIB Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population.
|
20520619 |
2010 |
|
rs2910164
|
|
Stage III Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population.
|
20520619 |
2010 |
|
rs2910164
|
|
Stage 0 Gallbladder Cancer AJCC v8
|
|
0.010 |
GeneticVariation
|
BEFREE |
Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population.
|
20520619 |
2010 |
|
rs2910164
|
|
Gallbladder Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population.
|
20520619 |
2010 |