|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
|
19018714 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia.
|
18602732 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia.
|
18596619 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of African-American subjects with schizophrenia for five BDNF coding region single nucleotide polymorphisms revealed variance only at the Val66Met</span> allele.
|
17894414 |
2008 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053).
|
19406621 |
2009 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to develop a simple, fast and accurate new method for detecting the Val66Met polymorphism of the BDNF gene in schizophrenia patients using melting-curve analysis and a DNA-specific dye, SYBR Green I.
|
19530966 |
2009 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study investigated the relationship between two polymorphisms, val66met in the BDNF coding region and -50T/C in the GSK-3beta promoter, and susceptibility to TD among a matched sample of patients having schizophrenia with TD (n = 83), patients with schizophrenia without TD (n = 78), and normal control subjects (n = 93).
|
19457211 |
2009 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
With the exception of nominally significant associations between BDNF Val66Met variation and PANSS total, negative, or general scores, no association between the BDNF Val66Met polymorphism and schizophrenia was found.
|
19359449 |
2009 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia.
|
19714565 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease.
|
20420877 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the Val66Met polymorphism was not associated with aggressiveness in patients with schizophrenia.
|
20579509 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task.
|
20708907 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia.
|
20957650 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
|
20430595 |
2010 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia.
|
21641949 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated.
|
21305693 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia.
|
21129438 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia.
|
21248641 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings.
|
21044653 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner.
|
21917241 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia.
|
21641949 |
2011 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients.
|
22521161 |
2012 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism.
|
22362486 |
2012 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have also performed the haplotype analysis with val66met BDNF polymorphism, which is known to be involved in the pathogenesis of schizophrenia.
|
21710362 |
2012 |
|
rs6265
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia.
|
22477643 |
2012 |