|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
In conclusion, whilst oncogenic KRAS mutation might activate Yap in other cell types, we could find no evidence for this in myoblasts because the expression of KRAS G12V expression did not change Yap/Taz activity in myoblasts and there was a limited overlap in gene expression between KRAS G12V and YAP1 S127A-driven tumours.
|
30353028 |
2018 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Disruption of Acvr1b in LSL-KRAS(G12D);Pdx1-Cre mice accelerated the growth of pancreatic IPMNs compared with LSL-KRAS(G12D);Pdx1-Cre mice, but did not alter growth of pancreatic intraepithelial neoplasias.
|
26408346 |
2016 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
The K-Ras(V14I) mutation is a mild activating K-Ras protein; thus, we have used this model to study tumour susceptibility in comparison with mice expressing the classical K-Ras(G12V) oncogene.
|
27174785 |
2016 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Coactivation of BRAF(V600E) and KRAS(G12D) markedly reduced lung tumor numbers and overall tumo</span>r burden compared with activation of BRAF(V600E) alone.
|
26028035 |
2016 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Orthotopic implantation of PDCs carrying the activated Kras(G12D</span>)-allele and shRNA against p16(Ink4a) or Trp53 resulted in tumor growth, metastasis, and reduced survival of NSG mice.
|
25724428 |
2015 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
We found that the deletion of Ink4a/Arf in K-Ras(G12D) expressing mice led to high expression of PDGF-D signaling pathway in the tumor and tumor-derived cell line (RInk-1 cells).
|
22806240 |
2013 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Both tumors develop in mice upon conditional deletion in melanocytes of Ink4a/Arf tumor suppressor genes with concomitant expression of oncogene H-Ras(G12V) and a known tumor antigen.
|
23173060 |
2012 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
|
17349581 |
2007 |
|
rs1444669684
|
|
Neoplasms
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, we identified a p14ARF exon 1beta missense germline mutation (G16D) in a melanoma-neural system tumour syndrome (CMM+NST) family and a 8474 bp germline deletion from 196 bp upstream of p14ARF exon 1beta initiation codon to 11233 bp upstream of exon 1alpha of p16(INK4A) in a family with five melanoma cases.
|
15937071 |
2006 |
|
rs1444669684
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.050 |
GeneticVariation
|
BEFREE |
A clinically translatable αvβ6-targeting NIRF agent was developed, based on a previously developed cysteine knottin peptide for PET imaging, R01-MG, and validated in preclinical mouse models.<b>Experimental Design:</b> The applicability of the agent was tested for cell and tissue binding characteristics using cell-based plate assays, subcutaneous, and orthotopic pancreatic models, and a transgenic mouse model of PDAC development (Pdx1-Cre<sup>tg/+</sup>;KRas<sup>LSL G12D/+</sup>;Ink4a/Arf<sup>-/-</sup>).
|
29298796 |
2018 |
|
rs1444669684
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.050 |
GeneticVariation
|
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
|
rs1444669684
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.050 |
GeneticVariation
|
BEFREE |
Compared with control, DNA synthesis and total cell proliferation was significantly increased in human PDCs harboring the PDAC common p53, Rb/p16(INK4a), and K-Ras (G12D) mutations.
|
23555182 |
2013 |
|
rs1444669684
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our previous study has shown that activation of Notch and NF-κB play a critical role in the development of PDAC in the compound K-Ras(G12D) and Ink4a/Arf deficient transgenic mice.
|
22806240 |
2013 |
|
rs1444669684
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
|
0.050 |
GeneticVariation
|
BEFREE |
Here, we report that pancreas-targeted IKK2/β inactivation inhibited NF-κB activation and PDAC development in Kras(G12D) and Kras(G12D);Ink4a/Arf(F/F) mice, demonstrating a mechanistic link between IKK2/β and Kras(G12D) in PDAC inception.
|
22264792 |
2012 |
|
rs1444669684
|
|
Pancreatic Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors.
|
26408346 |
2016 |
|
rs1444669684
|
|
Pancreatic Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
|
rs1444669684
|
|
Pancreatic Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
|
rs1444669684
|
|
Rhabdomyosarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
First, to compare YAP1 S127A and KRAS G12V-driven rhabdomyosarcomas, we re-analysed gene expression microarray datasets from mouse rhabdomyosarcomas caused by these genes.
|
30353028 |
2018 |
|
rs1444669684
|
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The data suggest that coexpression of BRAF(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene-induced senescence.
|
26028035 |
2016 |
|
rs1444669684
|
|
Adenocarcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Loss of the gene that encodes p16 (Cdkn2a) was required for progression of IPMNs to pancreatic ductal adenocarcinomas in Acvr1b(flox/flox);LSL-Kras(G12D);Pdx1-Cre mice.
|
26408346 |
2016 |
|
rs1444669684
|
|
Lung Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Coactivation of BRAF(V600E) and KRAS(G12D) markedly reduced lung tumor numbers and overall tumor burden compared with activation of BRAF(V600E) alone.
|
26028035 |
2016 |
|
rs1444669684
|
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.).
|
24213573 |
2014 |
|
rs1444669684
|
|
Lung Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Conditional deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung tumors in vivo.
|
24213573 |
2014 |
|
rs1444669684
|
|
Pancreatic Ductal Adenocarcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
|
rs1444669684
|
|
Pancreatic Ductal Adenocarcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Pancreatic ductal adenocarcinoma (PDAC) commonly contains a mutation in K-Ras(G12D) and is characterized by a desmoplastic reaction composed of deregulated, proliferating cells embedded in an abnormal extracellular matrix (ECM).
|
23555182 |
2013 |