Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.600 0.937 243 7 1990 2018
Entrez Id: 1630
Gene Symbol: DCC
DCC
P43146 DCC netrin 1 receptor 156 0.504 0.655 0.99 0.600 0.906 34 2 1990 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.400 0.963 494 7 1992 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.400 0.946 411 9 1989 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.400 0.956 318 4 1992 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.400 0.970 304 2 2002 2018
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 0.400 0.967 276 11 1993 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.400 0.953 171 5 1993 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 832 0.338 0.897 1.00 0.400 0.971 146 7 1998 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.400 1.000 120 1 2004 2018
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
P04818 thymidylate synthetase transferase 256 0.457 0.759 0.76 0.400 0.919 92 2 1997 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
P42898 methylenetetrahydrofolate reductase 699 0.354 0.828 1.2E-09 0.400 0.914 76 7 1997 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Q13485 SMAD family member 4 transcription factor 426 0.430 0.759 1.00 0.400 0.981 54 0 1996 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
P10415 BCL2, apoptosis regulator signaling molecule 987 0.312 0.862 0.57 0.400 1.000 49 0 1997 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 760 0.355 0.862 0.98 0.400 0.894 47 1 2002 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
P35222 catenin beta 1 412 0.417 0.759 1.00 0.400 1.000 46 0 1998 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 606 0.371 0.828 1.3E-05 0.400 0.923 40 5 1990 2018
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
P09488 glutathione S-transferase mu 1 423 0.403 0.828 2.0E-03 0.400 0.895 39 2 1995 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
P01375 tumor necrosis factor signaling molecule 1640 0.263 0.966 0.80 0.400 1.000 38 1 1989 2017
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
Q12882 dihydropyrimidine dehydrogenase oxidoreductase 191 0.520 0.690 5.7E-22 0.400 0.967 34 1 1998 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
P37231 peroxisome proliferator activated receptor gamma nucleic acid binding; receptor; transcription factor 540 0.388 0.828 0.14 0.400 0.882 34 4 2000 2015
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
O15105 SMAD family member 7 transcription factor 138 0.520 0.621 0.56 0.400 1.000 33 7 2001 2018
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
O43490 prominin 1 membrane traffic protein 306 0.450 0.793 2.4E-18 0.400 0.906 33 0 2008 2017
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
P01344 insulin like growth factor 2 505 0.399 0.828 4.7E-02 0.400 1.000 31 0 1996 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
P01137 transforming growth factor beta 1 signaling molecule 847 0.336 0.931 0.17 0.400 0.964 29 0 1994 2018