|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.
|
25365208 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the HLA-DP gene are associated with the natural clearance of the hepatitis B virus in Asian patients.
|
25109699 |
2014 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
|
23449268 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed a case-control study nested in a well-characterized cohort of booster recipients to assess whether genetic variants of HLA-DPB1 are also associated with response to hepatitis B (HB) vaccination.
|
23739870 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive).
|
23825586 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine the effect of HLA-DP polymorphisms on the generation of HBV mutations and their interactions on the outcomes of HBV infection. rs3077, rs3135021, rs9277535, and rs2281388 were genotyped in 1,342 healthy controls, 327 HBV clearance subjects, and 2,736 HBV-positive subjects, including 1,108 hepatocellular carcinoma (HCC) patients, using quantitative PCR.
|
24006435 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409).
|
23601003 |
2013 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.
|
24162738 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLA-DPB1 loci are associated with persistent HBV infection in Asian populations.
|
24023482 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The genome-wide association study (GWAS) variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene that associated most significantly with chronic hepatitis B and outcomes to HBV infection in Asians had a marginal effect on HBV recovery in our European- and African-American samples (odds ratio [OR] = 0.39, P = 0.01, combined ethnic groups).
|
22496224 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results further confirmed the strong influence of HLA-DP gene variants on risk of spontaneous HBV clearance from persistent HBV infection.
|
22543033 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4-1.9; p = 1).
|
22448225 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese.
|
21408128 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings indicated that variants in antigen-binding regions of HLA-DP and HLA-DQ contribute to the risk of persistent HBV infection.
|
21750111 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons.
|
21402545 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
|
21310144 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535).
|
21904616 |
2011 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |