AIMS To investigate the influence of ABCB1 (1236-2677-3435) polymorphisms on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers.
Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural hypotension (OR = 1.37, P = 0.042, 95% CI 1.01-1.86).
Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural hypotension (OR = 1.37, P = 0.042, 95% CI 1.01-1.86).
We performed autonomic evaluations in 4 patients with lifelong orthostatic hypotension in whom <i>CYB561</i> mutations were determined by genomic sequencing.
This study is the first to implicate cytochrome b561 in disease by showing that pathogenic mutations in <i>CYB561</i> cause an as yet unknown disease in neurotransmitter metabolism causing orthostatic hypotension.