|
rs6736587
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.
|
24124408 |
2013 |
|
rs6736587
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.
|
24124408 |
2013 |
|
rs1294950721
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1143623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
rs2682826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
rs3837091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygotes for <i>DDC</i> rs3837091 and <i>SLC22A1</i> rs628031 AA carriers also had higher odds for orthostatic hypotension (OR = 1.94; 95% CI = 1.07-3.51; <i>p</i> = 0.028 and OR = 2.57; 95% CI = 1.11-5.95; <i>p</i> = 0.028, respectively).
|
30745869 |
2019 |
|
rs4880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other associations observed were only nominally significant after adjustments: NOS1 rs2682826 A allele and excessive daytime sleepiness and sleep attacks (OR = 1.75; 95%CI = 1.00-3.06, p = 0.048), SOD2 rs4880 T allele and nausea/vomiting (OR = 0.49, 95%CI = 0.25-0.94; p = 0.031), IL1β rs1143623 C allele and orthostatic hypotension (OR = 0.57, 95%CI = 0.32-1.00, p = 0.050), and NOS1 rs2682826 A allele and impulse control disorders (OR = 2.59; 95%CI = 1.09-6.19; p = 0.032).
|
30813952 |
2019 |
|
rs628031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygotes for <i>DDC</i> rs3837091 and <i>SLC22A1</i> rs628031 AA carriers also had higher odds for orthostatic hypotension (OR = 1.94; 95% CI = 1.07-3.51; <i>p</i> = 0.028 and OR = 2.57; 95% CI = 1.11-5.95; <i>p</i> = 0.028, respectively).
|
30745869 |
2019 |
|
rs921451
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of at least one <i>DDC</i> rs921451 C allele and CT heterozygotes had higher odds for orthostatic hypotension (OR = 1.86; 95% CI = 1.07-3.23; <i>p</i> = 0.028 and OR = 2.30; 95% CI = 1.26-4.20; <i>p</i> = 0.007, respectively).
|
30745869 |
2019 |
|
rs1042713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of β2 -AR Arg16/Gly with OH was not significant after adjustment for conventional risk factors.
|
24552127 |
2014 |
|
rs1801253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that the β1 -AR Arg389/Gly polymorphism may be associated with increased risk of OH in female hypertensive patients.
|
24552127 |
2014 |
|
rs11191548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95% confidence interval: 0.90, 0.85-0.96; P = 0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.75-0.95; P = 0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.87-0.98; P= 0.009) loci.
|
22504314 |
2012 |
|
rs1173771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95% confidence interval: 0.90, 0.85-0.96; P = 0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.75-0.95; P = 0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.87-0.98; P= 0.009) loci.
|
22504314 |
2012 |
|
rs11953630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found Bonferroni adjusted (P < 0.0016) significant evidence for association between OH and the EBF1 locus (rs11953630, per-minor-allele odds ratio, 95% confidence interval: 0.90, 0.85-0.96; P = 0.001), and nominal evidence (P < 0.05) for CYP17A1 (rs11191548: 0.85, 0.75-0.95; P = 0.005), and NPR3-C5orf23 (rs1173771: 0.92, 0.87-0.98; P= 0.009) loci.
|
22504314 |
2012 |
|
rs17367504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.02-1.24; P = 0.02, rs198358: 1.10, 1.01-1.20; P = 0.04, and rs5068: 1.22, 1.04-1.43; P = 0.01).
|
22504314 |
2012 |
|
rs198358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.02-1.24; P = 0.02, rs198358: 1.10, 1.01-1.20; P = 0.04, and rs5068: 1.22, 1.04-1.43; P = 0.01).
|
22504314 |
2012 |
|
rs5068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among subjects not taking BP-lowering drugs, three SNPs within the NPPA/NPPB locus were nominally associated with increased risk of OH (rs17367504: 1.13, 1.02-1.24; P = 0.02, rs198358: 1.10, 1.01-1.20; P = 0.04, and rs5068: 1.22, 1.04-1.43; P = 0.01).
|
22504314 |
2012 |
|
rs759304648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a Japanese FAF patient with a missense mutation (G654A), presenting multiple cranial nerve symptoms, corneal lattice dystrophy, carpal tunnel syndrome and orthostatic hypotension.
|
19422734 |
2010 |
|
rs4149601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, rs4149601 is a genetic risk factor for hypertension and a protective factor against orthostatic hypotension in hypertensive subjects, and the antihypertensive response to hydrochlorothiazide is more sensitive in A allele carriers than in GG carriers.
|
19635985 |
2009 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between the maximum change in SBP, the prevalence of orthostatic hypotension and gene polymorphisms of angiotensin-converting enzyme I/D, angiotensinogen M235T and angiotensin II type 1 receptor A1166C.
|
11910300 |
2002 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between the maximum change in SBP, the prevalence of orthostatic hypotension and gene polymorphisms of angiotensin-converting enzyme I/D, angiotensinogen M235T and angiotensin II type 1 receptor A1166C.
|
11910300 |
2002 |