Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group RGD A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. 28007901 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group RGD Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. 27895165 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE To establish a reliable and appropriate in vivo model of aggressive human B-cell leukemia and lymphoma we xenotransplanted four p53-mutated cell lines and one ATM-mutated cell line into immunodeficient NOD/SCID IL2Rγ-null mice. 25827173 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE Although EμCyclinD1 is not sufficient to induce lymphomas, EμCyclinD1 accelerates the kinetics and increases the incidence of clonal lymphomas in ATM-deficient B-cells and skews the lymphomas toward pre-GC-derived small lymphocytic neoplasms, sharing morphological features of human MCL. 25676421 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE ATM(-/-) mice recapitulate lymphocytopenia of A-T patients and routinely succumb to thymic lymphomas with t(12;14) translocation, syntenic to inv(14;14) in humans. 25721125 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE In humans, ATM deficiency predisposes to B- and T-cell lymphomas, but in mice it leads only to thymic lymphomas. 24913718 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE Finally, we demonstrate that DNA-PKcs inhibitors are effective as single agents against ATM-defective lymphomas in vivo. 23761041 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE Biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), a complex neurological disease associated with a high risk of leukaemias and lymphomas. 19404735 2010
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE Overall, these data identify a novel molecular mechanism through which ATM kinase may regulate the immune system homeostasis and impair lymphoma development. 17932249 2008
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias. 17516749 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE We hypothesize that ATM function is slightly attenuated by some variants, which could reduce double-stranded break repair capacity, contributing to the occurrence of translocations and subsequent lymphomas. 17640065 2007
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE Inherited biallelic mutations of the ATM (ataxia-telangiectasia mutated) gene cause ataxia-telangiectasia, a rare autosomal recessive disorder associated with a high incidence of childhood leukaemias and lymphomas, suggesting that ATM gene alterations may be involved in lymphomagenesis. 14628072 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE ATM mutations have been reported in adult sporadic lymphoma and leukaemia. 14735203 2004
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. 12697903 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE The recurrent 11q22-23 deletions found in mantle cell lymphoma (MCL) suggest that ATM could be inactivated in these lymphomas. 11756177 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma. 12148890 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE Germ-line mutations in the ATM gene cause ataxia-telangiectasia (A-T), a multisystem disorder associated with predisposition to lymphoma and acute leukemia. 12149228 2002
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. 11429421 2001
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE A hemizygous ATM deletion was seen in 44% to 88% of the interphase cells in 15 cases (11.1%); four patients had an indolent lymphoma (follicular center cell lymphoma), and 11 patients had an aggressive lymphoma (five mantle-cell lymphomas [MCLs] and six diffuse large-cell lymphomas). 10893293 2000
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE To investigate a potential pathogenic role of ATM in B-cell tumorigenesis, we performed mutation analysis of ATM in 29 malignant lymphomas of B-cell origin (B-CLL = 27; mantle cell lymphoma, [MCL] = 2). 10397742 1999
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE We have found previously an overrepresentation (3.4%) of ATM mutations in a subset of 88 selected breast cancer patients with a family history of breast cancer, leukemia, and lymphoma. 9537233 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation group BEFREE The ATM gene deficient in ataxia-telangiectasia, a recessive multisystem disease associated with a high risk of lymphomas and leukemias, was found previously to be inactivated in a rare sporadic malignancy, T-cell prolymphocytic leukemia (T-PLL), which is often associated with cytogenetic aberrations of chromosome 14. 9622061 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 Biomarker group BEFREE While ATM plays a major role in signaling the p53 response to DNA strand break damage, Atm-/- p53(-/-) mice develop lymphomas earlier than Atm-/- or p53(-/-) mice, indicating that mutations in these two genes lead to synergy in tumorigenesis. 9632822 1998
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GenomicAlterations group CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 CausalMutation group CGI