Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 Biomarker disease BEFREE While the underlying cause of POAG remains unclear, TGF-β2-dependent remodeling of the extracellular matrix (ECM) within the trabecular meshwork (TM) microenvironment is considered an early pathologic consequence associated with impaired aqueous humor (AH) outflow and elevated IOP. 31433458 2019
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE During bilateral sequential cataract surgery, the AH of the second eye had a higher level of TGF-β2 but not of proinflammatory cytokines or chemokines compared with those in the first eye, implying a protective mechanism preventing the sympathetic immune reaction induced by the first-eye cataract surgery. 30973281 2019
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE However, within the AACG group, although the TGFβ2 levels in AH did not differ significantly from the control level when all AACG patients were grouped together, there were differences when the AACG patients were divided into high and normal intraocular pressure (IOP); TGFβ2 of AACG patients with high IOP (> 21 mmHg) was significantly higher than those with normal IOP. 31382918 2019
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE JIAUwG patients showed an increased level of TGFβ-2 in AH samples compared with JIAUwoG (<i>P</i> < 0.0009). 29675026 2018
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE The levels of active TGF-β2 in the AH of PPCD patients are significantly higher than control values, and thus the increased levels of TGF-β2 could be a consequence of the PPCD phenotype and can be considered as another feature characterizing this disease. 28414732 2017
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. 28159972 2017
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 Biomarker disease BEFREE Transforming growth factor β2 (TGFβ2) is elevated in the AH and TM of primary open angle glaucoma (POAG) patients and induces POAG-associated TM changes, including CLANs. 28241317 2017
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.080 AlteredExpression disease BEFREE Untreated uveitis and noninflammatory AqH up-regulated CXCR4 to a limited extent; this was dependent on TGF-beta2. 15153539 2004
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker disease BEFREE Using bead-based immunoassay analysis we were able to detect a significantly higher concentration of the B cell-activating and survival factors BAFF, APRIL, and IL-6 in the AqH of JIAU and AAU patients than in POAG patients. 30885419 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 AlteredExpression disease BEFREE And multivariate cox regression analysis revealed that high AH levels of MCP-1 was an independent predictor for postoperative inflammation relapse. 30288998 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 Biomarker disease BEFREE Even though visual acuity response and anatomic effect are not always correlated in DME, we found that baseline elevated MCP-1 AH levels and DRT pattern were biomarkers that predicted a future favorable anatomic response to DEX. 30933261 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 Biomarker disease BEFREE Relapsed DME cases (T3) showed significantly higher levels of IL-6 (<i>p</i> = .028), IL-8 (<i>p</i> = .005), IP-10 (<i>p</i> = .013) and MCP-1 (<i>p</i> = .005) compared to T2.<i>Conclusion</i>: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. 31418610 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.060 Biomarker disease BEFREE Usefulness of Liquid Biopsy Biomarkers from Aqueous Humor in Predicting Anti-VEGF Response in Diabetic Macular Edema: Results of a Pilot Study. 31684007 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 Biomarker disease BEFREE The levels of cytokines (interleukins [ILs]-1α, -1β, -4, -6, -8, -10, -12p70, -13, -17A, interferon [IFN]-α, IFN-γ, monocyte chemotactic protein [MCP]-1, E-selectin, P-selectin, and soluble intercellular adhesion molecule-1 [sICAM-1]) in the AqH were measured using multiplex beads immunoassay. 30316668 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.060 AlteredExpression disease BEFREE We observed a significant decrease in IL-10 levels in the AqH of patients with BU and a significant increase in VEGF levels in the AqH of patients with FUS compared to controls. 31065903 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 AlteredExpression disease BEFREE <i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased. 31268809 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 Biomarker disease BEFREE Reverse-transcription polymerase chain reactions, IHC staining, Western blot analysis, and ELISA showed that cilostazol inhibited mRNA and protein expressions of intercellular adhesion molecule-1, monocyte chemoattractant protein-1 and fractalkine in the retina and aqueous humor (AqH). 30373407 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 Biomarker disease BEFREE Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-γ, interleukin (IL)-10, and IL-6 levels by ELISA. 30081671 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 Biomarker disease BEFREE The levels of the cytokines (interleukin [IL]-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, interferon [IFN]-γ, monocyte chemotactic protein [MCP]-1, E-selectin, P-selectin, and soluble intercellular adhesion molecule [sICAM]-1) in the AqH were measured with multiplex beads immunoassay. 30262982 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.060 Biomarker disease BEFREE This system is applied to assess the angiogenic capacity of aqueous humor (AH) from patients with ocular disorders, and to test the effect of VEGF inhibitor (aflibercept) on induced angiogenesis. 29743587 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 AlteredExpression disease BEFREE In addition, higher percentages of CD4+IFN-γ+ and CD4+IL-17A+ T cells in the lymph nodes and spleens, as well as TNF, IFN-γ, IL-17A and IL-6 levels in the aqueous humor, significantly increase in mice with rejected corneal grafts. 29789580 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.060 AlteredExpression disease BEFREE Moreover, taurine reduced the VEGF level in human ocular aqueous humor. 29658345 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker disease BEFREE One hundred nineteen patients for whom IL-10 and IL-6 in the AH and/or vitreous had been measured were included: 16 patients with a final diagnosis of VRL and 103 patients with final diagnosis of uveitis. 29135797 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.060 Biomarker disease BEFREE To identify disease-specific cytokine profile differences in the aqueous humor (AH) (other than the vascular endothelial growth factor) between patients with dry and treated wet age-related macular degeneration (AMD) and healthy controls. 30157273 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 AlteredExpression disease BEFREE In addition, higher percentages of CD4+IFN-γ+ and CD4+IL-17A+ T cells in the lymph nodes and spleens, as well as TNF, IFN-γ, IL-17A and IL-6 levels in the aqueous humor, significantly increase in mice with rejected corneal grafts. 29789580 2018