Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 9332
Gene Symbol: CD163
CD163 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 958
Gene Symbol: CD40
CD40 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 968
Gene Symbol: CD68
CD68 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		0.010 GeneticVariation disease BEFREE The db/db-CDK4(R24C) mice present a novel model of leptin-resistant obesity with compensatory hyperinsulinemia and normalized blood glucose levels, and thus may be useful for future studies that aim to dissect relationships between insulin and leptin signaling. 18678431 2008
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R 		0.010 Biomarker disease BEFREE We used chemical (clodronate), genetics (CD169-diphtheria toxin receptor mice), or antibody-mediated (colony-stimulating factor 1 receptor α) macrophage ablation methods in diabetic (db/db) and diet-induced models of compensatory hyperinsulinemia to investigate the role of macrophages in islet remodeling. 31573842 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4 		0.010 GeneticVariation disease BEFREE In a randomized, double-blind, placebo-controlled study in humans, consumption of a propionate-containing mixed meal resulted in a postprandial increase in plasma glucagon, FABP4, and norepinephrine, leading to insulin resistance and compensatory hyperinsulinemia. 31019023 2019
Entrez Id: 2175
Gene Symbol: FANCA
FANCA 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 2176
Gene Symbol: FANCC
FANCC 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 2641
Gene Symbol: GCG
GCG 		0.300 Biomarker disease CTD_human Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. 3019152 1986
Entrez Id: 2746
Gene Symbol: GLUD1
GLUD1 		0.300 Biomarker disease CTD_human Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. 9571255 1998
Entrez Id: 2876
Gene Symbol: GPX1
GPX1 		0.300 Biomarker disease CTD_human Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. 18560803 2008
Entrez Id: 2876
Gene Symbol: GPX1
GPX1 		0.300 Biomarker disease CTD_human Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. 15184668 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.300 Therapeutic disease CTD_human Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. 19171794 2009
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene. 2991050 1985
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin. 3511099 1986
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. 6382002 1984
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia. 4019786 1985
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 AlteredExpression disease BEFREE The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. 30453495 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 Biomarker disease CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 Biomarker disease CTD_human Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. 18411068 2008
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 GeneticVariation disease BEFREE The findings on INSR rs2115386 are supportive of the role of insulin resistance, or the compensatory hyperinsulinemia, in the pathogenesis of DR. 27768789 2016