Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. 6382002 1984
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene. 2991050 1985
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia. 4019786 1985
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human "Estrone treatment dissociates primary versus secondary consequences of ""diabetes"" (db) gene expression in mice." 3519326 1986
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Biomarker disease CTD_human Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin. 3511099 1986
Entrez Id: 2641
Gene Symbol: GCG
GCG 		0.300 Biomarker disease CTD_human Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. 3019152 1986
Entrez Id: 2746
Gene Symbol: GLUD1
GLUD1 		0.300 Biomarker disease CTD_human Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. 9571255 1998
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 Biomarker disease CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat. 15093691 2004
Entrez Id: 2876
Gene Symbol: GPX1
GPX1 		0.300 Biomarker disease CTD_human Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. 15184668 2004
Entrez Id: 79661
Gene Symbol: NEIL1
NEIL1 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.320 Biomarker disease CTD_human Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. 18411068 2008
Entrez Id: 2876
Gene Symbol: GPX1
GPX1 		0.300 Biomarker disease CTD_human Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. 18560803 2008
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		0.010 GeneticVariation disease BEFREE The db/db-CDK4(R24C) mice present a novel model of leptin-resistant obesity with compensatory hyperinsulinemia and normalized blood glucose levels, and thus may be useful for future studies that aim to dissect relationships between insulin and leptin signaling. 18678431 2008
Entrez Id: 3667
Gene Symbol: IRS1
IRS1 		0.300 Biomarker disease CTD_human Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.300 Therapeutic disease CTD_human Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. 19171794 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Therapeutic disease CTD_human Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. 19008412 2009
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 2175
Gene Symbol: FANCA
FANCA 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 1831
Gene Symbol: TSC22D3
TSC22D3 		0.300 Biomarker disease CTD_human The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. 22556341 2012
Entrez Id: 2176
Gene Symbol: FANCC
FANCC 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 4160
Gene Symbol: MC4R
MC4R 		0.300 Biomarker disease CTD_human A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. 23251400 2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. 22949526 2012