Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease UNIPROT Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients. 27328445 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. 26822949 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. 26270727 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutation in the RAD51B gene confers predisposition to breast cancer. 24139550 2013
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic. 26057125 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. 12966089 2003
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. 22451500 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer. 28905878 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer. 27622768 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. 25292178 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease BEFREE With only one previously described homozygous RAD51C variant to date, our findings expand the phenotypic spectrum of FANCO and suggest it should be part of the antenatal differential diagnosis for trisomy 13 and 18, due to the presence of atypical findings such as cleft lip and palate, holoprosencephaly, growth restriction and overlapping fingers. 29278735 2018
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Inherited Mutations in Women With Ovarian Carcinoma. 26720728 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease UNIPROT Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. 24993905 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. 26354865 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan. 24800917 2014