Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease BEFREE With only one previously described homozygous RAD51C variant to date, our findings expand the phenotypic spectrum of FANCO and suggest it should be part of the antenatal differential diagnosis for trisomy 13 and 18, due to the presence of atypical findings such as cleft lip and palate, holoprosencephaly, growth restriction and overlapping fingers. 29278735 2018
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer. 26740214 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. 27433846 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR RAD51C is a susceptibility gene for ovarian cancer. 21616938 2011
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients. 27328445 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC). 24315737 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. 26822949 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. 26270727 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Screening for germline mutations in breast/ovarian cancer susceptibility genes in high-risk families in Israel. 26687385 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Germline mutation in the RAD51B gene confers predisposition to breast cancer. 24139550 2013
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer. 26824983 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Mutation Analysis of the RAD51C and RAD51D Genes in High-Risk Ovarian Cancer Patients and Families from the Czech Republic. 26057125 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075 2017
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. 12966089 2003
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer. 25452441 2015
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. 22451500 2012
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 CausalMutation disease CLINVAR Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. 26822949 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		0.710 GeneticVariation disease CLINVAR Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer. 28905878 2017