Disease: Familial Alzheimer Disease (FAD)
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
CST3 P01034 cystatin C 3.9E-03 0.436 0.808
HFE Q30201 homeostatic iron regulator 2.6E-08 0.436 0.846
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885
ANXA1 P04083 annexin A1 1.2E-07 0.442 0.885
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923
PTK2B Q14289 protein tyrosine kinase 2 beta Kinase 0.94 0.448 0.808
PRKCB P05771 protein kinase C beta Kinase 1.00 0.453 0.885
WWOX Q9NZC7 WW domain containing oxidoreductase Enzyme 1.2E-15 0.453 0.808
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846
PYCARD Q9ULZ3 PYD and CARD domain containing Enzyme 2.0E-04 0.457 0.808
EHMT1 Q9H9B1 euchromatic histone lysine methyltransferase 1 Epigenetic regulator 1.00 0.460 0.808
CREB1 P16220 cAMP responsive element binding protein 1 1.00 0.463 0.885
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
DNM1L O00429 dynamin 1 like Enzyme modulator 5.7E-04 0.475 0.808
CTSD P07339 cathepsin D Enzyme 9.2E-04 0.478 0.846
FANCD2 Q9BXW9 FA complementation group D2 1.1E-30 0.479 0.885
KNG1 P01042 kininogen 1 Enzyme modulator 3.2E-10 0.481 0.885
SERPINA3 P01011 serpin family A member 3 Enzyme modulator 8.8E-14 0.486 0.846
NEFL P07196 neurofilament light 0.488 0.769
ADAM10 O14672 ADAM metallopeptidase domain 10 1.00 0.489 0.846
IL12A P29459 interleukin 12A 4.7E-02 0.491 0.808
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769