|
rs10505477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis by histological lesion revealed the association of rs10505477 and rs6983267 variants with reduced risk of low- and high-risk adenomas in controls, being this effect stronger in low-risk adenomas (log-additive models, OR:0.63, 95%CI:0.47-0.84 and OR:0.64, 95%CI:0.47-0.86, respectively).
|
30194776 |
2019 |
|
rs10795668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low-risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06-0.72, and OR:0.08, 95%CI:0.03-0.61) and controls (dominant models, OR:0.50, 95%CI:0.34-0.75, and OR:0.52, 95%CI:0.35-0.78, respectively).
|
30194776 |
2019 |
|
rs11255841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low-risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06-0.72, and OR:0.08, 95%CI:0.03-0.61) and controls (dominant models, OR:0.50, 95%CI:0.34-0.75, and OR:0.52, 95%CI:0.35-0.78, respectively).
|
30194776 |
2019 |
|
rs142287570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs150766139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The carrier of c.268C>T (p.Q90*) and 550-1G>A was diagnosed with CRC and meningioma at ages 37 and 45 respectively, being reclassified as attenuated adenomatous polyposis after the cumulative detection of 26 adenomas.
|
31227763 |
2019 |
|
rs371918069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs61734277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs1201299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At rs1201299 in ADIPOQ, the AC genotype had a higher risk (OR 1.58, 95%CI 1.00-2.49) of adenomas, while the minor AA genotype had a borderline inverse association (OR 0.44, 95%CI 0.18-1.08; reference: CC).
|
29802748 |
2018 |
|
rs1927911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three TLR4 tagSNPs (rs10116253, rs1927911, rs7873784) were associated with adenomas among obese participants.
|
29802748 |
2018 |
|
rs7873784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three TLR4 tagSNPs (rs10116253, rs1927911, rs7873784) were associated with adenomas among obese participants.
|
29802748 |
2018 |
|
rs121913279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we report measurements of PIK3CA H1047R mutant fraction (MF) in normal colonic mucosa, normal lung, colonic adenomas, colonic adenocarcinomas, and lung adenocarcinomas.
|
28755461 |
2017 |
|
rs121913409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four APAs showed a predominant (≥50%) zona fasciculata-like cell pattern: one tumor had CYP11B1 H-score = 150, no detectable CYP11B2 expression, and harbored a PRKACA p.Leu206Arg mutation (that we have reported previously elsewhere), one had no CYP11B1 expression, CYP11B2 H-score = 40, and no mutations; the remaining two adenomas had high CYP11B1 H-score (160 and 240, respectively) and low CYP11B2 H-score (30 and 15, respectively), with the latter harboring a CTNNB1 p.Ser45Phe activating mutation.
|
28405879 |
2017 |
|
rs2720574
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The P values for interactions between calcium:magnesium intake ratio and rs2720574 were .002 for all adenomas and <.001 for multiple/advanced adenoma.
|
28501704 |
2017 |
|
rs386834263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A zona glomerulosa-like APA harbored a known CACNA1D G403R somatic mutation, whereas a zona reticularis-like adenoma, which was grossly black in pigmentation with histologic characteristics more associated with cortisol-producing adenomas, expressed CYP11B2, CYP17, and DHEA-ST by immunohistochemistry (IHC) and harbored no known somatic mutations.
|
28368480 |
2017 |
|
rs4952490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an inverse association between calcium intake (1000-2000 mg/day) and colorectal adenomas, particularly for multiple/advanced adenomas, among the G-allele carriers but not among homozygous carriers of the common variant (A) in rs4952490.
|
28544176 |
2017 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effect of vitamin D3 supplementation on advanced adenomas, but not on adenoma risk overall, significantly varied according to genotype at 2 VDR SNPs (rs7968585 and rs731236) in linkage disequilibrium (D' = 0.98; r2 = 0.6).
|
27978548 |
2017 |
|
rs7968585
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effect of vitamin D3 supplementation on advanced adenomas, but not on adenoma risk overall, significantly varied according to genotype at 2 VDR SNPs (rs7968585 and rs731236) in linkage disequilibrium (D' = 0.98; r2 = 0.6).
|
27978548 |
2017 |
|
rs2959656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We discovered a significant association (OR=17.8, CI 0.95=2.18-145.5, P=0.0002) between a rare MEN1 mutation (rs2959656) and clinically active adenoma in our patients.
|
27185868 |
2016 |
|
rs7131056
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs7131056 in DRD2 contributes to either faster growth of the adenoma or reduced symptomatic presentation, allowing PAs to become larger before detection.
|
27185868 |
2016 |
|
rs1268298845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively).
|
25822476 |
2015 |
|
rs1290398674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The hyperplastic gland showed a PRKACA(L206R) mutation, while patients with bilateral adenomas did not have known somatic mutations.
|
25750087 |
2015 |
|
rs146462069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemistry showed increased IGSF1 staining in the GH-producing tumor from the patient with the IGSF1 p.N604T variant compared with a GH-producing adenoma from a patient negative for any IGSF1 variants and with normal control pituitary tissue.
|
25527509 |
2015 |
|
rs3802842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation.
|
24801760 |
2015 |
|
rs121918464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atypical adenomatous hyperplasia and small adenomas were observed in CCSP-rtTA/tetO-SHP2(E76K) bitransgenic mice induced with Dox for 2-6 months and progressed to larger adenoma and adenocarcinoma by 9 months.
|
24480804 |
2014 |
|
rs2855798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In combined analysis of phases I and II, the P values for interactions between calcium intake and rs2855798 were 1 × 10(-4) for all adenoma and 5 × 10(-3) for multiple/advanced adenoma.
|
25165391 |
2014 |