|
rs1051740
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
rs2234922
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
rs34612342
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively).
|
25822476 |
2015 |
|
rs1268298845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively).
|
25822476 |
2015 |
|
rs386834263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A zona glomerulosa-like APA harbored a known CACNA1D G403R somatic mutation, whereas a zona reticularis-like adenoma, which was grossly black in pigmentation with histologic characteristics more associated with cortisol-producing adenomas, expressed CYP11B2, CYP17, and DHEA-ST by immunohistochemistry (IHC) and harbored no known somatic mutations.
|
28368480 |
2017 |
|
rs371918069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs142287570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs61734277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activating GCM2 CCID variants (p.V382M and p.Y394S) were identified in six of 396 adenomas (1.52%), and a hyperparathyroidism-associated GCM2 non-CCID activating variant (p.Y282D) was found in 20 adenomas (5.05%).
|
30624640 |
2019 |
|
rs2276020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a silent polymorphism, D172D (c.516C>T), was found in 3 patients with non-functioning adenoma, in 2 patients with prolactinoma and in one patient with acromegaly.
|
18484068 |
2008 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Almost all of seven studies of colorectal adenoma have found no association between C677T polymorphism and adenoma, but the 677TT genotype seems to be related to increased risk when folate status is poor.
|
16128738 |
2005 |
|
rs121912532
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although several LHR mutations have been reported in testotoxicosis, the D578H-LHR mutation, which has been found only as a somatic mutation, appears up until now to be specifically responsible for Leydig cell adenomas.
|
21490077 |
2011 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Among 379 cases and 726 controls, MTHFR genotypes were not appreciably related to risk of adenoma, but a suggestive interaction (P = 0.09) was observed between MTHFR 677C-->T and alcohol intake; men with TT homozygotes who consumed 30+ g/day of alcohol had an odds ratio (OR) of 3.52 [95% confidence interval (CI), 1.41-8.78] relative to drinkers of < or =5 g/day with the CC/CT genotypes.
|
14578131 |
2003 |
|
rs17503908
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the top findings, an SNP (rs17503908) in ataxia telangiectasia mutated (ATM) was inversely related to adenoma risk (OR = 0.75, 95% CI = 0.63-0.91).
|
21504893 |
2011 |
|
rs6586714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction was observed between 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) intake and the NAT1 polymorphism rs6586714 in the adenoma study (P(interaction) = 0.001).
|
22552404 |
2012 |
|
rs1535989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional variant associated with advanced adenomas, rs1535989 [minor allele frequency, 0.11; OR, 2.09; 95% confidence interval (CI), 1.50-2.91], also predicted colorectal cancer development in a validation analysis (P = 0.019) using a series of adenoma cases or colorectal cancer (CORGI study) and 3 sets of colorectal cancer cases and controls (Scotland, VQ58, and Australia; N = 9,211).
|
24084763 |
2013 |
|
rs142163070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.
|
16118341 |
2005 |
|
rs4539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.
|
16118341 |
2005 |
|
rs763539313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.
|
16118341 |
2005 |
|
rs1205
|
|
|
0.020 |
GeneticVariation |
BEFREE |
At rs1205 in CRP, T (minor allele) carriers had a higher risk (OR 1.67, 95%CI 1.07-2.60; reference: CC) of adenomas overall and adenomas with aggressive characteristics.
|
29802748 |
2018 |
|
rs1201299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At rs1201299 in ADIPOQ, the AC genotype had a higher risk (OR 1.58, 95%CI 1.00-2.49) of adenomas, while the minor AA genotype had a borderline inverse association (OR 0.44, 95%CI 0.18-1.08; reference: CC).
|
29802748 |
2018 |
|
rs121918464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atypical adenomatous hyperplasia and small adenomas were observed in CCSP-rtTA/tetO-SHP2(E76K) bitransgenic mice induced with Dox for 2-6 months and progressed to larger adenoma and adenocarcinoma by 9 months.
|
24480804 |
2014 |
|
rs778826879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Atypical adenomatous hyperplasia and small adenomas were observed in CCSP-rtTA/tetO-SHP2(E76K) bitransgenic mice induced with Dox for 2-6 months and progressed to larger adenoma and adenocarcinoma by 9 months.
|
24480804 |
2014 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V599E mutation was found in 27 serrated adenomas (77.1%), and KRAS mutations were found in 3 (8.6%) of 35 traditional serrated adenomas.
|
15991007 |
2005 |
|
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V599E mutation was found in 27 serrated adenomas (77.1%), and KRAS mutations were found in 3 (8.6%) of 35 traditional serrated adenomas.
|
15991007 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E mutation analysis was performed in 148 selected cases; mutations were found in 44/49 (90%) of lesions diagnosed as sessile serrated adenoma, in 10/34 (29%) of hyperplastic polyps of microvesicular type, in 4/11 (36%) of traditional serrated adenomas, in 10/10 (100%) of mixed hyperplastic adenomatous polyps, and in 2/42 (5%) of "conventional" adenomas.
|
19126563 |
2009 |