|
rs11255841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 2 SNPs (rs10795668, rs11255841) in the noncoding LINC00709 gene were significantly associated with a reduced risk of low-risk adenomas in cases (recessive models, OR:0.22, 95%CI:0.06-0.72, and OR:0.08, 95%CI:0.03-0.61) and controls (dominant models, OR:0.50, 95%CI:0.34-0.75, and OR:0.52, 95%CI:0.35-0.78, respectively).
|
30194776 |
2019 |
|
rs1535989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An additional variant associated with advanced adenomas, rs1535989 [minor allele frequency, 0.11; OR, 2.09; 95% confidence interval (CI), 1.50-2.91], also predicted colorectal cancer development in a validation analysis (P = 0.019) using a series of adenoma cases or colorectal cancer (CORGI study) and 3 sets of colorectal cancer cases and controls (Scotland, VQ58, and Australia; N = 9,211).
|
24084763 |
2013 |
|
rs719725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs719725 was statistically significantly associated with risk of colorectal cancer in WHI (OR per A allele 1.19; 95% CI, 1.01-1.40; P(trend) = 0.04), marginally associated with adenoma risk in PLCO (OR per A allele 1.11; 95% CI, 0.99-1.25; P(trend) = 0.07), and not associated in DALS and MinnCCS.
|
20978172 |
2010 |
|
rs3789243
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using a case-control design, the association between the MDR1 intron 3 G-rs3789243-A polymorphism and the risk of colorectal carcinomas and adenomas in the Norwegian population was assessed in 167 carcinomas, 990 adenomas, and 400 controls.
|
19250544 |
2009 |
|
rs3789243
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The ABCB1 C-rs3789243-T and NFKB1 -94ins/del homozygous variant genotypes were associated with low ABCB1 mRNA levels in morphologically normal sigmoid tissue from adenoma cases (P<0.05 for both).
|
23977225 |
2013 |
|
rs104894194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, two out of nine patients with prolactin-producing adenoma were shown to harbor a Finnish founder mutation (Q14X) with a complete loss of the wild-type allele in the tumors.
|
17914118 |
2007 |
|
rs2276020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a silent polymorphism, D172D (c.516C>T), was found in 3 patients with non-functioning adenoma, in 2 patients with prolactinoma and in one patient with acromegaly.
|
18484068 |
2008 |
|
rs10941112
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regular ibuprofen users who were homozygous for the variant allele at either M9V or D175G were at reduced risk for adenoma (both P(interaction) < 0.05).
|
17684125 |
2007 |
|
rs1800497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1799732 CT and rs1800497 TT genotypes were significantly associated with adenoma recurrence in the Polyp Prevention Trial.
|
19065655 |
2009 |
|
rs1801155
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, compared with noncarriers, APC I1307K carriers had increased numbers of adenomas and colorectal cancers per patient (P=.03), as well as a younger age at diagnosis.
|
9973276 |
1999 |
|
rs1801155
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We postulated that some c.3920T>A carriers with multiple adenomas have other unidentified APC germ line or somatic mutations.
|
24416237 |
2014 |
|
rs1801155
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibrium.
|
12533826 |
2003 |
|
rs1801155
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The high frequency of I1307K colorectal cancer patients found in the Ashkenazi Jewish community of Ottawa and the equivalent proportion of carriers and noncarriers who developed adenomatous polyps suggest that in this community, I1307K is associated with a significant predisposition to carcinoma but not adenoma.
|
11159880 |
2001 |
|
rs1801155
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, APC I1307K carriers had greater numbers of adenomas and colorectal cancers per patient than noncarriers.
|
17854661 |
2007 |
|
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, APC I1307K carriers had greater numbers of adenomas and colorectal cancers per patient than noncarriers.
|
17854661 |
2007 |
|
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The high frequency of I1307K colorectal cancer patients found in the Ashkenazi Jewish community of Ottawa and the equivalent proportion of carriers and noncarriers who developed adenomatous polyps suggest that in this community, I1307K is associated with a significant predisposition to carcinoma but not adenoma.
|
11159880 |
2001 |
|
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, compared with noncarriers, APC I1307K carriers had increased numbers of adenomas and colorectal cancers per patient (P=.03), as well as a younger age at diagnosis.
|
9973276 |
1999 |
|
rs1463038513
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibrium.
|
12533826 |
2003 |
|
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The risk of harboring adenoma(s) among subjects bearing the E1317Q variant was 1.29 (95% CI 0.09-18.0).
|
12537656 |
2002 |
|
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study, 608 cases (377 patients with CRC, 145 patients with 4-100 lifetime adenomas, and 86 with < or =3 lifetime ade</span>nomas), and 679 controls (362 spouses and 317 patients with normal colonoscopy) were screened for the APC E1317Q variant.
|
14578138 |
2003 |
|
rs1268298845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively).
|
25822476 |
2015 |
|
rs459552
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic association between D1</span>822V</span> and advanced distal adenoma was confined to persons consuming a high-fat diet (P(interaction)=0.03).
|
20510605 |
2010 |
|
rs17503908
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the top findings, an SNP (rs17503908) in ataxia telangiectasia mutated (ATM) was inversely related to adenoma risk (OR = 0.75, 95% CI = 0.63-0.91).
|
21504893 |
2011 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V599E mutation was found in 27 serrated adenomas (77.1%), and KRAS mutations were found in 3 (8.6%) of 35 traditional serrated adenomas.
|
15991007 |
2005 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BRAF V600E mutation is one of the most frequent molecular abnormalities identified in hyperplastic polyps and sessile serrated adenomas.
|
26030242 |
2015 |