Gene: APC ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs62619935
rs62619935
APC
T 0.710 CausalMutation CLINVAR

dbSNP: rs121913224
rs121913224
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs121913327
rs121913327
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854573
rs137854573
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854575
rs137854575
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs1400295986
rs1400295986
APC
0.700 GeneticVariation UNIPROT

dbSNP: rs145945630
rs145945630
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs1554085355
rs1554085355
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs397515734
rs397515734
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs587781392
rs587781392
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs779998847
rs779998847
APC
0.700 GeneticVariation UNIPROT

dbSNP: rs786201856
rs786201856
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs863225311
rs863225311
APC
G 0.700 GeneticVariation CLINVAR

dbSNP: rs876660765
rs876660765
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. 9407954

1997
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. 9288102

1997
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE The I1307K APC mutation does not predispose to colorectal cancer in Jewish Ashkenazi breast and breast-ovarian cancer kindreds. 9407954

1997
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer. 9679946

1998
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2). 9731533

1998
dbSNP: rs1801155
rs1801155
APC
A 0.800 SusceptibilityMutation CLINVAR The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462). 9679945

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Interestingly, the I1307K APC polymorphism, associated with an increased risk of colorectal cancer, is also present in this family. 9831355

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE The I1307K allele was found in 6.1% of unselected Ashkenazi Jews and higher proportions of Ashkenazim with family or personal histories of CRC (ref.2). 9731533

1998
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer. 9679946

1998
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462). 9679945

1998