Gene: APC ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs62619935
rs62619935
APC
T 0.710 CausalMutation CLINVAR

dbSNP: rs121913224
rs121913224
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs121913327
rs121913327
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854573
rs137854573
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs137854575
rs137854575
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs1400295986
rs1400295986
APC
0.700 GeneticVariation UNIPROT

dbSNP: rs145945630
rs145945630
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs1554085355
rs1554085355
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs397515734
rs397515734
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs587781392
rs587781392
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs779998847
rs779998847
APC
0.700 GeneticVariation UNIPROT

dbSNP: rs786201856
rs786201856
APC
T 0.700 CausalMutation CLINVAR

dbSNP: rs863225311
rs863225311
APC
G 0.700 GeneticVariation CLINVAR

dbSNP: rs876660765
rs876660765
APC
A 0.700 CausalMutation CLINVAR

dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE I1307K is a founder genetic variant in Jews of different ethnic origin, mainly Ashkenazim, but it explains only partially their higher incidence of colorectal carcinoma. 12173321

2002
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE I1307K is a founder genetic variant in Jews of different ethnic origin, mainly Ashkenazim, but it explains only partially their higher incidence of colorectal carcinoma. 12173321

2002
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE A missense mutation within the APC gene, I1307K, was described in Ashkenazi individuals at risk for colorectal cancer (CRC) and in the general population. 11551102

2001
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE A missense mutation within the APC gene, I1307K, was described in Ashkenazi individuals at risk for colorectal cancer (CRC) and in the general population. 11551102

2001
dbSNP: rs777980327
rs777980327
APC
0.040 GeneticVariation BEFREE Activating V600E mutation in BRAF gene has been linked with widespread methylation of CpG islands in sporadic colorectal cancers. 21455633

2011
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462). 9679945

1998
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE Among the 1087 first-degree relatives, there were 23 cases of colorectal cancer; 3 of 100 relatives of probands with the I1307K allele (3.0%) had a history of colorectal cancer versus 20 of 987 relatives of probands without the I1307K allele (2.1%; relative risk, 1.48; 95% confidence interval, 0.45-4.88; P = 0.462). 9679945

1998
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population. 10343885

1999
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population. 10343885

1999
dbSNP: rs1801155
rs1801155
APC
0.800 GeneticVariation BEFREE An association between a missense mutation, APC I1307K, and the risk of sporadic colorectal cancer (CRC) has been reported. 22180177

2012
dbSNP: rs1463038513
rs1463038513
APC
0.100 GeneticVariation BEFREE An association between a missense mutation, APC I1307K, and the risk of sporadic colorectal cancer (CRC) has been reported. 22180177

2012