Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis. 22123460

2011

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease. 22045428

2011

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE We tested the clinical relevance of the PON1 Q192R genotype in a population of individuals with coronary artery disease who underwent stent implantation and received clopidogrel therapy. 21170047

2011

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the atherosclerosis risk in communities study. 21982484

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T polymorphism of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. 20637366

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease. 20642368

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population. 20470943

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The G894T polymorphism in the eNOS gene might influence coronary atherosclerosis rather than ICAS in Koreans. 21114134

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. 20083095

2010

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease. 19434512

2010

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE A preliminary study of human paraoxonase and PON 1 L/M55-PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease. 19226538

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes. 18586656

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with early onset of coronary artery disease in some populations with certain ethnic backgrounds. 18751630

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity. 18403793

2008

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE The M235T polymorphism of the AGT gene modifies the risk of coronary artery disease associated with the presence of hypercholesterolemia. 18409009

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization. 17604826

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians. 18075008

2007

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease. 16842840

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population. 15935452

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease. 15648053

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to a mild rise in plasma homocysteine levels and increase the incidence of coronary artery disease. 16489563

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The oxidative modification of low-density lipoprotein (LDL) has been suggested to be a key element in atherogenesis, while methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with the development of coronary heart disease. 16487909

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The objective of our study is to evaluate the single locus and combined effects of three different genetic polymorphisms (methylenetetrahydrofolate reductase C677T polymorphism, plasminogen activator inhibitor 4G/5G polymorphism, and endothelial nitric oxide synthase 3-27 base pairs repeat polymorphism) on the presence and extent of coronary artery disease in patients with early-onset coronary artery disease. 16845248

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07). 17108813

2006