|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Pro</span>12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Pro</span>12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects.
|
10843155 |
2000 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
|
11289058 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
|
11289058 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the A allele of P12A polymorphism was 0.16 and the t allele of c1431t polymorphism, 0.13 in patients with type 2 diabetes, and 0.13 and 0.12 respectively in subjects without diabetes 3.2% of patients with and 1.4% without type 2 diabetes were A12A.
|
11409297 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the A allele of P12A polymorphism was 0.16 and the t allele of c1431t polymorphism, 0.13 in patients with type 2 diabetes, and 0.13 and 0.12 respectively in subjects without diabetes 3.2% of patients with and 1.4% without type 2 diabetes were A12A.
|
11409297 |
2001 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both diabetes populations were typed for the PPARg Pro12Ala polymorphism, to replicate this well-supported association (Altshuler et al.2000).
|
12096349 |
2002 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both diabetes populations were typed for the PPARg Pro12Ala polymorphism, to replicate this well-supported association (Altshuler et al.2000).
|
12096349 |
2002 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes.
|
14729856 |
2004 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes.
|
14729856 |
2004 |
|
rs3856806
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes.
|
14729856 |
2004 |
|
rs3856806
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We have shown previously that the linked T allele of the C1431T polymorphism influences Ala12-associated diabetes risk and that the 2 polymorphisms have opposing associations with body weight.
|
15486307 |
2004 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We determined, by polymerase chain reaction (PCR), the Pro12Ala PPARgamma2 and the eNOS 4a/b gene polymorphisms in a total of 395 patients with diabetes mellitus 2 (DM2) (225 men and 170 women) from the LIANCO (Lipid-Analytic-Cologne) study.
|
15662218 |
2005 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We determined, by polymerase chain reaction (PCR), the Pro12Ala PPARgamma2 and the eNOS 4a/b gene polymorphisms in a total of 395 patients with diabetes mellitus 2 (DM2) (225 men and 170 women) from the LIANCO (Lipid-Analytic-Cologne) study.
|
15662218 |
2005 |
|
rs121909244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a randomized, placebo-controlled, double-blind, crossover study, 24 subjects with type 2 diabetes and one subject with partial lipodystrophy and diabetes due to dominant-negative mutation in the peroxisome proliferator-activated receptor-gamma (PPARgamma) gene (P467L) received placebo and rosiglitazone for 3 months.
|
15855323 |
2005 |
|
rs3856806
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Based on published data from four populations, the date of origin of the diabetes protective PPARG Ala12 variant was estimated using both allele frequency and linkage disequilibrium (LD) with the C1431T single nucleotide polymorphism in exon 6 of the PPARG gene.
|
15994875 |
2005 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.
|
16316841 |
2005 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.
|
16316841 |
2005 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |