|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes risk alleles in PPAR-γ2 (rs1801282) and PTPRD (rs17584499) are associated with pioglitazone therapeutic efficacy.
|
23147557 |
2013 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes.
|
21877956 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial.
|
22017455 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population.
|
23006958 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial.
|
22017455 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population.
|
23006958 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes.
|
21877956 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings shows the association of these two polymorphisms with serum triglyceride levels, which was increased in the order of P12P-CC < P12P-CT < P12A-CC < P12A-CT in the CHD patients with diabetes.
|
21833536 |
2011 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
|
21795447 |
2011 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings shows the association of these two polymorphisms with serum triglyceride levels, which was increased in the order of P12P-CC < P12P-CT < P12A-CC < P12A-CT in the CHD patients with diabetes.
|
21833536 |
2011 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
|
21795447 |
2011 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes.
|
20406760 |
2010 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes.
|
20406760 |
2010 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers.
|
19436234 |
2009 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers.
|
19436234 |
2009 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.
|
17941898 |
2008 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The P12A variant of isoform gamma is estimated to reduce diabetes risk by 19% in many populations, and has a large attributable risk because of high prevalence of the normal allele.
|
18388689 |
2008 |