Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs955333
rs955333
0.710 GeneticVariation BEFREE <i>Background</i>.Genome-wide association studies found rs955333 located in 6q25.2 was associated with diabetic kidney disease in multiple ethnic populations, including European Americans, African Americans, and Mexican Americans. 28401168

2017

dbSNP: rs12523822
rs12523822
0.710 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs12523822
rs12523822
0.710 GeneticVariation BEFREE Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). 26305897

2016

dbSNP: rs955333
rs955333
0.710 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs10019835
rs10019835
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs10952362
rs10952362
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs1298908
rs1298908
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs13254600
rs13254600
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs136161
rs136161
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs2780902
rs2780902
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs5750250
rs5750250
0.700 GeneticVariation GWASCAT Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND). 26305897

2016

dbSNP: rs6930576
rs6930576
0.700 GeneticVariation GWASCAT A genome-wide association study for diabetic nephropathy genes in African Americans. 21150874

2011

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE NOS3 894G>T polymorphism is associated with progression of kidney disease and cardiovascular morbidity in type 2 diabetic patients: NOS3 as a modifier gene for diabetic nephropathy? 24603156

2014

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854

2013

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects. 20049477

2011

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively. 19773668

2009

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy. 18622262

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene variants with diabetic nephropathy. 18413207

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE These results suggest that the eNOS gene locus is associated with diabetic nephropathy and the functional polymorphisms (-786T > C & 894G > T) might lead to a decreased expression of eNOS gene. 18401556

2008

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy. 17101543

2007

dbSNP: rs1799983
rs1799983
0.090 GeneticVariation BEFREE Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy. 15331206

2005

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM. 21942443

2012

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE The present study has investigated the role of endothelial nitric oxide (eNOS) G894T polymorphism and its interaction with methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C variants on the predisposition to diabetic nephropathy and its progression. 21380725

2011

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE A1298C allele and genotype distribution were comparable between DN and DWN patients in both communities. 20524928

2010

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. 16828193

2007