|
rs121434254
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygous mutations of AIRE were identified in 3 patients: a patient with PBC and a patient with AIH type 1 carried a R257X mutation, and a patient with AIH type 2, diabetes mellitus type 1 (IDDM), thyroid disease, and atrophic gastritis carried a G305S mutation in the first PHD ring finger domain of the AIRE protein.
|
11343230 |
2001 |
|
rs1440526066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05-2.21), compared with homozygotes of the high activity allele.
|
17006724 |
2006 |
|
rs764097618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05-2.21), compared with homozygotes of the high activity allele.
|
17006724 |
2006 |
|
rs765803011
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05-2.21), compared with homozygotes of the high activity allele.
|
17006724 |
2006 |
|
rs2297518
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nonsynonymous SNP of NOS2A (Ser608Leu) and an SNP located in the promoter of IFNGR1 (C-56T) were associated with higher risk of atrophic gastritis [odds ratio (OR)=1.37, 95% confidence interval (CI)=1.01-1.86, and OR=1.49, 95% CI=1.01-2.19, respectively].
|
18287876 |
2008 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis.
|
18755634 |
2008 |
|
rs2301756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study aimed to examine the formerly reported association of G/A PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) with gastric atrophy, as well as the association with gastric cancer in a Japanese population using a large sample size.
|
19589142 |
2009 |
|
rs2301756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our previous studies found the AA genotype of a G/A single nucleotide polymorphism at intron 3 (rs2301756) of PTPN11 gene, which encodes SHP-2, to be associated with a lower risk of gastric atrophy.
|
18712962 |
2009 |
|
rs6672420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no statistically significant associations between RUNX3 rs6672420 polymorphism and risk of gastric atrophy, nor between these two RUNX3 polymorphisms and the risk of gastric cancer relative to the subjects with gastric atrophy.
|
19728008 |
2009 |
|
rs760805
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese.
|
19728008 |
2009 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.
|
20845517 |
2010 |
|
rs3805246
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We could not confirm a major association between Gab1 SNP (rs3805246) and the predisposition to H. pylori infection and CAG in this study population from Germany.
|
20602450 |
2010 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study revealed the combined effect of miR-146a rs2910164 G/G and TLR4 +3725 C allele on the increased risk of severe gastric atrophy among the H. pylori-infected Japanese subjects.
|
20721625 |
2011 |
|
rs12423190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides the first evidence that rs12423190 polymorphism of the PTPN11 gene is significantly associated with an increased risk of gastric atrophy in H. pylori infected Chinese Han population, suggesting that rs12423190 polymorphism could be used as a useful marker of genetic susceptibility to gastric atrophy among H. pylori infected subjects.
|
22788847 |
2012 |
|
rs2014486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped MUC1 T31T, MUC2 L58P, MUC2 V116M, MUC5B E34G, MUC5B R51W, MUC5B rs2014486 (intronic) and MUC6 V619M for 533 serologically defined CAG cases and 1054 age- and sex-matched controls.
|
21596555 |
2012 |
|
rs7481521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped MUC1 T31T, MUC2 L58P, MUC2 V116M, MUC5B E34G, MUC5B R51W, MUC5B rs2014486 (intronic) and MUC6 V619M for 533 serologically defined CAG cases and 1054 age- and sex-matched controls.
|
21596555 |
2012 |
|
rs2294008
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03-2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13-1.98 for the dominant model).
|
24023815 |
2013 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In gastric cancerous specimens, we observed significantly higher messenger RNA level in the subjects carrying the PGC rs6458238 GA genotype than that in subjects with the common GG genotype.
|
23455381 |
2013 |
|
rs1042194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs10505799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs12229892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to GA and/or GC.
|
23455381 |
2013 |
|
rs254942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the ERCC4 rs6498486 and rs254942 may be associated with AG risk.
|
23415627 |
2013 |
|
rs3814896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first report of an association between the TFF2 rs3814896 AG+GG genotypes and decreased risks of GC, diffuse-type GC, and atrophic gastritis in younger people aged ≤ 50 years, and an association between TFF3 rs9981660 AG+AA genotype and decreased risk of diffuse-type GC in men.
|
23933418 |
2013 |
|
rs4711690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to GA and/or GC.
|
23455381 |
2013 |
|
rs6498486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the ERCC4 rs6498486 and rs254942 may be associated with AG risk.
|
23415627 |
2013 |