|
rs6878265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs9315542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively.
|
23801863 |
2013 |
|
rs9981660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first report of an association between the TFF2 rs3814896 AG+GG genotypes and decreased risks of GC, diffuse-type GC, and atrophic gastritis in younger people aged ≤ 50 years, and an association between TFF3 rs9981660 AG+AA genotype and decreased risk of diffuse-type GC in men.
|
23933418 |
2013 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs10739971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A two-stage case-control study was designed to screen four miRNA SNPs (pri-let-7a-2 rs629367 and rs1143770, pri-let-7a-1 rs10739971, pri-let-7f-2 rs17276588) in 107 GC patients, 107 atrophic gastritis (AG), and matched 124 controls using PCR-RFLP.
|
24760009 |
2014 |
|
rs10739971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs1917799
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs9471643
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs10983755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a case-control study, we analyzed the genotypic distribution of TLR4 rs10983755 (-2081G/A) and rs11536878 in a Chinese population and investigated the effect of their interactions with Helicobacter pylori infection on susceptibility to gastric cancer (GC) and atrophic gastritis (AG).
|
25084512 |
2014 |
|
rs11536878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11536878 polymorphism was not associated with GC or AG.
|
25084512 |
2014 |
|
rs17276588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A two-stage case-control study was designed to screen four miRNA SNPs (pri-let-7a-2 rs629367 and rs1143770, pri-let-7a-1 rs10739971, pri-let-7f-2 rs17276588) in 107 GC patients, 107 atrophic gastritis (AG), and matched 124 controls using PCR-RFLP.
|
24760009 |
2014 |
|
rs3789210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
|
25551587 |
2014 |
|
rs629367
|
|
|
0.010 |
GeneticVariation |
BEFREE |
pri-let-7a-2 rs629367 CC genotype could increase the risks of gastric cancer as well as atrophic gastritis and was also associated with poor survival of gastric cancer, which possibly by affecting the mature let-7a expression, and could serve as a predicting biomarker for high-risk and poor prognosis of gastric cancer.
|
24760009 |
2014 |
|
rs6939861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
|
25551587 |
2014 |
|
rs2294008
|
|
|
0.720 |
GeneticVariation |
BEFREE |
PSCA rs2294008 C>T polymorphism was assessed in H. pylori-positive Japanese patients (n = 488) with noncardia gastric cancer (n = 193), gastric ulcer (n = 84), duodenal ulcer (n = 61), and atrophic gastritis (n = 150), as well as in H. pylori-negatives (n = 266).
|
25582162 |
2015 |
|
rs158572
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis comparing the common genotype revealed significantly increased gastric cancer risk in males and individuals older than 50 years with rs158572 GA/GG/GG+GA genotypes, while individuals older than 50 years with rs158916 CT/CC+CT genotypes were less susceptible to atrophic gastritis.
|
26130415 |
2015 |
|
rs158916
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis comparing the common genotype revealed significantly increased gastric cancer risk in males and individuals older than 50 years with rs158572 GA/GG/GG+GA genotypes, while individuals older than 50 years with rs158916 CT/CC+CT genotypes were less susceptible to atrophic gastritis.
|
26130415 |
2015 |
|
rs1130233
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In H. pylori-negative individuals, the AKT rs1130233 GA and (GA+AA) genotypes were related to increased risk of atrophic gastritis (AG; P = 0.012, P = 0.024).
|
26317520 |
2015 |
|
rs4833095
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, subjects carrying TLR1 rs4833095 TT genotype were associated with reduced risks of chronic atrophic gastritis (CAG, OR=0.66; 95%CI: 0.45-0.97) and intestinal metaplasia (IM, OR=0.57; 95%CI: 0.36-0.90).
|
25687912 |
2015 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two pairwise combinations of miRNA and PGC SNPs were associated with increased AG risk (let-7e rs8111742 - PGC rs6458238 and miR-4795 rs1002765 - PGC rs9471643).
|
26988755 |
2016 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Additionally, rs6458238 AG/AA genotype was associated with reduced atrophic gastritis risk in dominant model.
|
25857852 |
2016 |
|
rs9471643
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two pairwise combinations of miRNA and PGC SNPs were associated with increased AG risk (let-7e rs8111742 - PGC rs6458238 and miR-4795 rs1002765 - PGC rs9471643).
|
26988755 |
2016 |
|
rs1002765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the miRNAs SNPs (let-7e rs8111742 and miR-4795 rs1002765) might have more superior efficiency when combined with PGC SNPs and/or H. pylori for GC or AG risk than a single SNP on its own.
|
26988755 |
2016 |
|
rs121224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Singly, miR-365b rs121224 and PGC rs6912200 had no effect individually but in combination they demonstrated an epistatic interaction associated with AG risk.
|
26988755 |
2016 |
|
rs2029298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis suggested that DDB2 rs2029298-rs326222-rs3781619-rs830083 GTAG haplotype was significantly associated with disease risk in each step of CON→AG→GC development (AG vs. CON: OR=2.88, P= 7.51 × 10-7; GC vs. AG: OR=2.90, P=5.68 × 10-15; GC vs. CON: OR=8.42, P=2.22 × 10-15); DDB2 GTAC haplotype was associated with reduced risk of GC compared with CON (OR=0.63, P= 8.31 × 10-12).
|
26760766 |
2016 |