|
rs2294008
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy.
|
30753327 |
2019 |
|
rs2294008
|
|
|
0.720 |
GeneticVariation |
BEFREE |
PSCA rs2294008 C>T polymorphism was assessed in H. pylori-positive Japanese patients (n = 488) with noncardia gastric cancer (n = 193), gastric ulcer (n = 84), duodenal ulcer (n = 61), and atrophic gastritis (n = 150), as well as in H. pylori-negatives (n = 266).
|
25582162 |
2015 |
|
rs2294008
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03-2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13-1.98 for the dominant model).
|
24023815 |
2013 |
|
rs2920283
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy.
|
30753327 |
2019 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two pairwise combinations of miRNA and PGC SNPs were associated with increased AG risk (let-7e rs8111742 - PGC rs6458238 and miR-4795 rs1002765 - PGC rs9471643).
|
26988755 |
2016 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Additionally, rs6458238 AG/AA genotype was associated with reduced atrophic gastritis risk in dominant model.
|
25857852 |
2016 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs6458238
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In gastric cancerous specimens, we observed significantly higher messenger RNA level in the subjects carrying the PGC rs6458238 GA genotype than that in subjects with the common GG genotype.
|
23455381 |
2013 |
|
rs158572
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, ERCC6 rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk.
|
28562347 |
2017 |
|
rs158916
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, ERCC6 rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk.
|
28562347 |
2017 |
|
rs1917799
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, ERCC6 rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk.
|
28562347 |
2017 |
|
rs9471643
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two pairwise combinations of miRNA and PGC SNPs were associated with increased AG risk (let-7e rs8111742 - PGC rs6458238 and miR-4795 rs1002765 - PGC rs9471643).
|
26988755 |
2016 |
|
rs158572
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis comparing the common genotype revealed significantly increased gastric cancer risk in males and individuals older than 50 years with rs158572 GA/GG/GG+GA genotypes, while individuals older than 50 years with rs158916 CT/CC+CT genotypes were less susceptible to atrophic gastritis.
|
26130415 |
2015 |
|
rs158916
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratified analysis comparing the common genotype revealed significantly increased gastric cancer risk in males and individuals older than 50 years with rs158572 GA/GG/GG+GA genotypes, while individuals older than 50 years with rs158916 CT/CC+CT genotypes were less susceptible to atrophic gastritis.
|
26130415 |
2015 |
|
rs10739971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A two-stage case-control study was designed to screen four miRNA SNPs (pri-let-7a-2 rs629367 and rs1143770, pri-let-7a-1 rs10739971, pri-let-7f-2 rs17276588) in 107 GC patients, 107 atrophic gastritis (AG), and matched 124 controls using PCR-RFLP.
|
24760009 |
2014 |
|
rs10739971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs1917799
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs9471643
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs2301756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study aimed to examine the formerly reported association of G/A PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) with gastric atrophy, as well as the association with gastric cancer in a Japanese population using a large sample size.
|
19589142 |
2009 |
|
rs2301756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our previous studies found the AA genotype of a G/A single nucleotide polymorphism at intron 3 (rs2301756) of PTPN11 gene, which encodes SHP-2, to be associated with a lower risk of gastric atrophy.
|
18712962 |
2009 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is a multifarious interaction between the DNA repair gene <i>ERCC5</i> SNPs (rs2094258 and rs873601) and the metabolic gene <i>GSTP1</i> rs1695, which may form the basis for various inter-individual susceptibilities to AG.
|
29434449 |
2018 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL10 gene promoter -819C/T (rs1800871) polymorphism was associated with the risk of GC and AG in a Chinese population.
|
30205739 |
2018 |
|
rs2094258
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is a multifarious interaction between the DNA repair gene <i>ERCC5</i> SNPs (rs2094258 and rs873601) and the metabolic gene <i>GSTP1</i> rs1695, which may form the basis for various inter-individual susceptibilities to AG.
|
29434449 |
2018 |
|
rs7521584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7521584 TT genotype was significantly associated with the development of atrophic gastritis [odds ratio (OR), 2.41; 95% confidence interval (CI), 1.10‑5.25; P=0.027), particularly in patients with H. pylori infection (OR, 3.31; 95% CI, 1.35‑8.12; P=0.0089).
|
29956763 |
2018 |
|
rs873601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is a multifarious interaction between the DNA repair gene <i>ERCC5</i> SNPs (rs2094258 and rs873601) and the metabolic gene <i>GSTP1</i> rs1695, which may form the basis for various inter-individual susceptibilities to AG.
|
29434449 |
2018 |