|
rs37369
|
|
|
0.020 |
GeneticVariation |
BEFREE |
AGXT2 rs37369 polymorphism is associated with increased risk for CHF, which may due to distinct disparities of alleles in ADMA degradation.
|
27423328 |
2016 |
|
rs671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure.
|
27742538 |
2017 |
|
rs10501920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, rs10501920 in CNTN5 was associated with AF (p = 9.4 x 10(-6)) and HF (p = 1.2 x 10(-4)).
|
17903304 |
2007 |
|
rs2149954
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, nominally significant associations between the rs2149954 minor allele and a decreased risk of heart attack and heart failure as well as increased physical functioning were found in the long-lived individuals.
|
28100865 |
2017 |
|
rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among individuals of African or Hispanic/Latino ancestry enrolled in 2 academic medical center-based biobanks, the TTR V122I genetic variant was significantly associated with heart failure.
|
31821430 |
2019 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study.
|
12921807 |
2003 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure.
|
17145981 |
2007 |
|
rs1800206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the peroxisome proliferator-activated receptor α gene L162V polymorphism with stage C heart failure.
|
21430558 |
2011 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure.
|
12767551 |
2003 |
|
rs548787835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At 6 months of age when congestive heart failure is apparent in R120G mice, both LC3-II flux and TFEB activities were severely suppressed, while mTORC1 activity increased.
|
31297061 |
2019 |
|
rs1042713
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure.
|
19886995 |
2009 |
|
rs1800888
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly and Thr164Ile were suggested to have an effect in heart failure.
|
19886995 |
2009 |
|
rs7311358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Blood samples were collected for the analysis of trough SDC (immunofluorescence) and the polymorphisms of OATP1B1 388A>G, OATP1B1 521T>C, and OATP1B3 699G>A (PCR-RFLP and Sanger sequencing).Patients with glomerular filtration rate (GFR) under 30 mL/min had significantly higher trough SDC (1.20 ± 0.50 ng/mL) than recommended trough SDC for heart failure patients.
|
30946364 |
2019 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype).
|
29754666 |
2018 |
|
rs2306235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CKIP-1 rs2306</span>235 polymorphism may be a risk factor for chronic heart failure in a Chi</span>nese Han population.
|
28402261 |
2017 |
|
rs1799998
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Clinical data, echocardiographic measurements, and a genetic sample for determination of CYP11B2 -344T>C (rs1799998) genotype and genetic ancestry were collected from 194 self-reported African Americans with chronic, ambulatory heart failure.
|
23936266 |
2013 |
|
rs9303504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards models adjusted for established clinical risk factors and genomic ancestry tested the independent association of rs9909004 or rs9303504 and the variant interactions with cornerstone HF pharmacotherapies (beta-blockers or angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) in additive genetic models.
|
31728800 |
2019 |
|
rs1801252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Data from our study suggest that the β adrenoreceptor Gly 49 allele of the β1 -adrenergic receptor Ser(49) Gly polymorphisms may increase the risk of ICD shock in patients with heart failure, independent of beta-blocker dosage.
|
27027728 |
2016 |
|
rs121918598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Development of HF was not aggravated by increased SR Ca<sup>2+</sup> leak due to RyR2 mutation (R2474S) in volume overload, an SR Ca<sup>2+</sup> leak-independent HF model.
|
30209242 |
2018 |
|
rs104894229
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome.
|
17054105 |
2007 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease.
|
25612295 |
2015 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls.
|
20079452 |
2010 |
|
rs2276109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For MMP12 -82A>G (rs2276109), no pharmacogenetic effect was found for the primary outcome, although lower HRs were observed for AA homozygotes in the chlorthalidone-amlodipine comparison for HF (P = 0.015).
|
21887284 |
2011 |
|
rs1800779
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For NOS3 -922 A>G (rs1800779), a higher HR was found in minor allele carriers for heart failure (AA = 1.00, AG+GG = 1.10 (CI = 1.00-1.21), P = 0.046).
|
22470539 |
2012 |
|
rs749303395
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Frequencies of AMPD1 C34T mutation, as well as novel A99G, G512A, IVS4-6delT, and C784T sequence alterations, were similar in the three groups, but 860T mutated allele was less frequent in the combined CAD+ HF- and HF+ groups than in the controls (1.7% vs. 4.3%, p=0.040).
|
21108053 |
2011 |