|
rs6929846
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10(-7)) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI.
|
21211798 |
2011 |
|
rs6929846
|
|
|
0.780 |
GeneticVariation |
GWASDB |
The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population.
|
21211798 |
2011 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The CDKN2A/B locus (rs2383207, 9p21), identified initially as a susceptibility allele for MI and recently implicated in large vessel stroke, was associated with macroscopic infarct pathology in our autopsy cohort (OR = 1.26, p = 0.031).
|
24135527 |
2013 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified 2 single-nucleotide polymorphisms (SNPs) on chromosome arm 9p21, rs10757278, and rs2383207 that confer susceptibility to myocardial infarction.
|
23454037 |
2013 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Subjects with the rs2383207 GG genotype had a 1.85-fold (P = 0.021) risk for MI when compared with the subjects with the AA genotype.
|
21415773 |
2011 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction.
|
18459066 |
2009 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We related SNPs rs2383207 and rs10757278 to stroke and to myocardial infarction and coronary revascularizations (coronary events) using crude and multivariate adjusted Cox proportional hazards models.
|
19293724 |
2009 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America.
|
18048766 |
2008 |
|
rs2383207
|
|
|
0.770 |
GeneticVariation |
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
rs2569512
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10(-7)) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI.
|
21211798 |
2011 |
|
rs2569512
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We showed that the C→T polymorphism (rs6929846) of BTN2A1 and A→G polymorphism (rs2569512) of ILF3 were significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study.
|
21557786 |
2011 |
|
rs2569512
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Similar analyses revealed that rs2569512 of ILF3 was significantly associated with MI in individuals with low (P = 0.0066; OR = 1.47) or high (P = 0.0013; OR = 1.88) triglycerides; in individuals with low (P = 0.0059; OR = 1.96) or high (P = 0.0020; OR = 1.51) HDL cholesterol; and in individuals with low (P = 0.0004, OR = 1.62) LDL cholesterol, but not in those with high LDL cholesterol.
|
21468600 |
2011 |
|
rs2569512
|
|
|
0.740 |
GeneticVariation |
GWASDB |
The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population.
|
21211798 |
2011 |
|
rs2569512
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Results suggested that the association of rs6929846 in BTN2A1 with MI was more apparent in low-risk individuals than in high-risk individuals, whereas the association of rs2569512 in ILF3 with MI was not influenced by the absence or presence of hypertension, DM or CKD.
|
21347509 |
2011 |
|
rs1333045
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Out of the eight studied SNPs, two, rs10757274_A [0.915 (0.840-1.00); p = 0.042], rs1333045_T [0.92(0.84-1.00); p = 0.048] were initially associated with type 2 diabetes but lost the association after multivariate adjustments for CAD, hypertension and MI, while rs10757274_A showed borderline association with hypertension.
|
30510472 |
2018 |
|
rs1333045
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
rs1333045
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Two other SNPs on the same gene, rs10757274_G [0.79(0.73-0.86); p = 2.98E-08] and rs1333045_C [0.79(0.73-0.86); p = 1.15E-08] as well as the rs9982601_T [1.38(1.23-1.55); p = 3.49E-08] on KCNE2 were associated with MI.
|
26708285 |
2016 |
|
rs9925481
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
|
21211798 |
2011 |
|
rs9925481
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In individuals without CKD, an initial screen by the Chi-square test revealed that the Cyright curved arrow T polymorphism of CLEC16A (rs9925481) and the Aright curved arrow G polymorphism of LAMA3 (rs12373237) were significantly (false discovery rate for allele frequencies of <0.05) associated with MI.
|
20372818 |
2010 |
|
rs9925481
|
|
|
0.730 |
GeneticVariation |
BEFREE |
An initial screen by the chi-square test revealed that the A-->G polymorphism of SEMA3F (rs12632110), the C-->T polymorphism of CLEC16A (rs9925481), the A-->G polymorphism of LAMA3 (rs12373237), and the C-->G polymorphism of PCSK2 (rs6080699) were significantly (false discovery rate for allele frequencies of <0.05) associated with MI.
|
20036365 |
2010 |
|
rs9925481
|
|
|
0.730 |
GeneticVariation |
BEFREE |
The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that three different polymorphisms were significantly (P<0.005) associated with the prevalence of MI in individuals with or without hypertension or diabetes mellitus: the C --> T polymorphism of CLEC16A (rs9925481) in individuals without hypertension, the A --> G polymorphism of SEMA3F (rs12632110) in individuals without diabetes mellitus and the A --> G polymorphism of ALOX5 (rs7913948) in individuals without hypertension or diabetes mellitus.
|
19787205 |
2009 |
|
rs1333045
|
|
|
0.730 |
GeneticVariation |
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
rs12373237
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
|
21211798 |
2011 |
|
rs1333040
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Multivariate permutation analyses demonstrated that the risk T allele of rs1333040 and G allele of rs2383207 were associated with MI (P = 0.045 and 0.002, respectively).
|
21415773 |
2011 |