Gene: SDHC ×
Source: CLINVAR ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD. 29386252

2018
dbSNP: rs201286421
rs201286421
SDHC
T 0.700 CausalMutation CLINVAR Polymyalgia rheumatica and vagal paraganglioma. 28412079

2017
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR Adrenocortical carcinoma and succinate dehydrogenase gene mutations: an observational case series. 28819017

2017
dbSNP: rs201286421
rs201286421
SDHC
T 0.700 CausalMutation CLINVAR Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients. 27279923

2016
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR Identification of eight novel SDHB, SDHC, SDHD germline variants in Danish pheochromocytoma/paraganglioma patients. 27279923

2016
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR A SDHC Founder Mutation Causes Paragangliomas (PGLs) in the French Canadians: New Insights on the SDHC-Related PGL. 27700540

2016
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2α SIGNALING. 26492543

2016
dbSNP: rs786205147
rs786205147
SDHC
A 0.700 GeneticVariation CLINVAR Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. 26173966

2016
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations. 25394176

2015
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. 25494863

2015
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations. 25394176

2015
dbSNP: rs201286421
rs201286421
SDHC
T 0.700 CausalMutation CLINVAR Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. 24781345

2014
dbSNP: rs201286421
rs201286421
SDHC
T 0.700 CausalMutation CLINVAR The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3). 24758179

2014
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing. 24728327

2014
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas. 24102379

2014
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3). 24758179

2014
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR Phenotypic variability and risk of malignancy in SDHC-linked paragangliomas: lessons from three unrelated cases with an identical germline mutation (p.Arg133*). 24423348

2014
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis. 24096523

2014
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Succinate dehydrogenase deficiency is rare in pituitary adenomas. 24625421

2014
dbSNP: rs786203457
rs786203457
SDHC
G 0.700 GeneticVariation CLINVAR Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients. 25025441

2014
dbSNP: rs786205147
rs786205147
SDHC
A 0.700 GeneticVariation CLINVAR Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) - a review. 24886695

2014
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome. 23175444

2013
dbSNP: rs587778661
rs587778661
SDHC
T 0.700 GeneticVariation CLINVAR A comprehensive next generation sequencing-based genetic testing strategy to improve diagnosis of inherited pheochromocytoma and paraganglioma. 23666964

2013
dbSNP: rs755235380
rs755235380
SDHC
G 0.700 CausalMutation CLINVAR Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation. 23282968

2013
dbSNP: rs764575966
rs764575966
SDHC
T 0.700 CausalMutation CLINVAR Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation. 23282968

2013