Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6094710
rs6094710 		0.720 GeneticVariation BEFREE To functionally characterize the osteoarthritis (OA) susceptibility variants that map to a region of high linkage disequilibrium (LD) on chromosome 20q13 marked by the single-nucleotide polymorphism (SNP) rs6094710 and encompassing NCOA3 and SULF2. 26211391

2015
dbSNP: rs6094710
rs6094710 		0.720 GeneticVariation BEFREE The expression and DNA methylation of NCOA3 in knee OA cartilage and in vitro dedifferentiated chondrocytes with or without rs6094710 SNP were analyzed by qRT-PCR, immunoblotting, methylation-specific PCR and bisulfite sequencing. 30261507

2018
dbSNP: rs6094710
rs6094710 		A 0.720 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. 23989986

2014
dbSNP: rs10492367
rs10492367 		0.710 GeneticVariation BEFREE The KLHDC5/PTHLH rs10492367 OA risk allele was associated with a wider upper femur in the whole shape model (P = 1 × 10<sup>-5</sup> ). 29882636

2018
dbSNP: rs10492367
rs10492367 		0.710 GeneticVariation GWASDB Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
dbSNP: rs10948155
rs10948155 		0.700 GeneticVariation GWASDB Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. 22566624

2012
dbSNP: rs12154055
rs12154055 		G 0.700 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
dbSNP: rs12618428
rs12618428 		0.700 GeneticVariation GWASDB Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
dbSNP: rs12923310
rs12923310 		0.700 GeneticVariation GWASDB Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
dbSNP: rs150365637
rs150365637 		GT 0.700 GeneticVariation GWASCAT Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. 29559693

2018
dbSNP: rs1627411
rs1627411 		0.700 GeneticVariation GWASDB Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
dbSNP: rs1913707
rs1913707 		A 0.700 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
dbSNP: rs2785988
rs2785988 		A 0.700 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
dbSNP: rs330050
rs330050 		G 0.700 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
dbSNP: rs35206230
rs35206230 		T 0.700 GeneticVariation GWASCAT Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. 30664745

2019
dbSNP: rs4072286
rs4072286 		0.700 GeneticVariation GWASDB Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. 22763110

2012
dbSNP: rs4931462
rs4931462 		0.700 GeneticVariation GWASDB Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. 22566624

2012
dbSNP: rs614332
rs614332 		C 0.700 GeneticVariation GWASCAT Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. 29559693

2018
dbSNP: rs80057746
rs80057746 		T 0.700 GeneticVariation GWASCAT Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. 29559693

2018
dbSNP: rs7775228
rs7775228 		0.020 GeneticVariation BEFREE Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. 20305777

2010
dbSNP: rs7775228
rs7775228 		0.020 GeneticVariation BEFREE The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals. 21853121

2011
dbSNP: rs1024611
rs1024611 		0.010 GeneticVariation BEFREE In conclusion, CCL2 gene polymorphisms (rs1024611 and rs4586) confer susceptibility to OA and may be potential markers for early diagnosis of OA. 31495394

2019
dbSNP: rs11564299
rs11564299 		0.010 GeneticVariation BEFREE In summary, a CDH2 promoter polymorphism influences the risk of OA, and hnRNP K was found to be involved in the regulation of elevated N-cadherin expression in patients with OA carrying the minor allele of rs11564299. 24148886

2014
dbSNP: rs116855380
rs116855380 		0.010 GeneticVariation BEFREE NCOA3 is subject to a cis-acting expression quantitative trait locus in articular cartilage, which correlates with the OA association signal and with the OA-associated allele of the functional SNP rs116855380, a SNP that is located only 10.3 kb upstream of NCOA3. 26211391

2015
dbSNP: rs2057768
rs2057768 		0.010 GeneticVariation BEFREE The results suggested that the IL-4R rs2057768 SNP could contribute to OA susceptibility in the Romanian population, providing novel evidence for the involvement of IL-4/IL-4R pair in the pathogenesis of OA. 30186498

2018