|
rs4140564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The top seven associations were subsequently tested in samples from the Netherlands (306 cases and 584 controls). rs4140564 on chromosome 1 mapping 5' to both the PTGS2 and PLA2G4A genes was associated with risk of knee OA in all the cohorts studied (overall odds ratio OR(mh) = 1.55 95% C.I.1.30-1.85, p < 6.9 x 10(-7)).
|
18471798 |
2008 |
|
rs4764133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The DNA variant near the MGP gene was validated in three additional studies, which resulted in a highly significant association between the MGP variant and hand OA (rs4764133, Beta<sub>meta</sub>=0.83, P<sub>meta</sub>=1.8*10<sup>-15</sup>).
|
28855172 |
2017 |
|
rs643472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current research genotyped four SNPs in 306 OA patients and 316 healthy controls, including PRNCR1 rs7463708, PRNCR1 rs1456315, PRNCR1 rs16901946 and KIF13B1 rs643472, to investigate their associations with OA susceptibility.
|
29714128 |
2018 |
|
rs6766414
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the comparison of hypertrophic with non-hypertrophic OA the most significant variant was located between <i>STT3B</i> and <i>GADL1</i> (rs6766414, p=3.13×10<sup>-6</sup>, OR (95% CIs) 1.45 (1.24 to 1.69)).
|
27974301 |
2017 |
|
rs9350591
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.
|
26346884 |
2015 |
|
rs4343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant correlation exists between ACE rs4343 and rs4362 polymorphisms and OA.
|
26261641 |
2015 |
|
rs4362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant correlation exists between ACE rs4343 and rs4362 polymorphisms and OA.
|
26261641 |
2015 |
|
rs1800682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA.
|
29734947 |
2018 |
|
rs2234767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fas (rs1800682) and FasL (rs763110) polymorphism were associated with the risk of IVDD and Fas (rs2234767) was correlated to the susceptibility of OA and RA.
|
29734947 |
2018 |
|
rs1871054
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, we have identified that the rs1871054 variant within the ADAM12 gene is a risk factor for increased osteoarthritis susceptibility and severity.
|
25667922 |
2015 |
|
rs1871054
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs1871054 polymorphism was not related to OA susceptibility or to progression traits.
|
19268722 |
2009 |
|
rs1871054
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that the rs1871054 was significantly associated with the risk of knee OA (allele model OR 1.72, 95% CI 1.43-2.07, P < 0.001; additive model: OR 2.06, 95% CI 1.19-3.56, P = 0.010; dominant model: OR 2.45, 95% CI 1.85-3.25, P < 0.001; recessive model: OR 1.54, 95% CI 1.13-2.10, P = 0.007). rs1044122 was significantly associated with knee OA susceptibility in recessive model (OR 1.45, 95% CI 1.03-2.04, P = 0.031).
|
28748424 |
2017 |
|
rs1871054
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, our data demonstrated the ADAM12 rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.
|
25197389 |
2014 |
|
rs3740199
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We conclude that rs3740199 polymorphism may affect occurrence of knee OA and its progression.
|
19268722 |
2009 |
|
rs3740199
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the stratified analysis by gender, significant association was identified with the risk of knee OA for rs3740199 in men in allele model (OR 2.41, 95% CI 1.51-3.84, P < 0.001), dominant model (OR 2.68, 95% CI 1.17-6.14, P = 0.02) and recessive model (OR 3.51, 95% CI 1.68-7.36, P = 0.001), but not for additive model (OR 1.30, 95% CI 0.81-2.08, P = 0.28).
|
28748424 |
2017 |
|
rs3740199
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs3740199 in ADAM12 was associated with knee OA susceptibility in Thai male patients, and individuals with the CC genotype carried the highest risk when compared with the GG and GC genotypes.
|
26875044 |
2016 |
|
rs1044122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the rs1871054 was significantly associated with the risk of knee OA (allele model OR 1.72, 95% CI 1.43-2.07, P < 0.001; additive model: OR 2.06, 95% CI 1.19-3.56, P = 0.010; dominant model: OR 2.45, 95% CI 1.85-3.25, P < 0.001; recessive model: OR 1.54, 95% CI 1.13-2.10, P = 0.007). rs1044122 was significantly associated with knee OA susceptibility in recessive model (OR 1.45, 95% CI 1.03-2.04, P = 0.031).
|
28748424 |
2017 |
|
rs1278279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For rs3740199 and rs1278279, no significant associations with knee OA were found.
|
28748424 |
2017 |
|
rs4747096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the nsSNP rs4747096 in ADAMTS14 was associated with knee OA in female Thai patients; therefore, the role of ADAMTS14 in OA seems to be gender-dependent.
|
24301791 |
2013 |
|
rs11807350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
|
27706574 |
2016 |
|
rs4233367
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
|
27706574 |
2016 |
|
rs226794
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
|
27706574 |
2016 |
|
rs226794
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Initial analyses of 2 sample collections (n = 277 and n = 159) showed a trend toward decreased frequency of the putative deleterious allele of rs226794 among patients with severe knee OA (P = 0.047 versus controls).
|
18240210 |
2008 |
|
rs226794
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs2830585 polymorphism, but not rs226794 polymorphism, was significantly associated with an increased risk of knee OA.
|
30652828 |
2019 |
|
rs2830585
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the ADAMTS5 rs2830585 polymorphism may be involved in the development of knee OA by destroying the extracellular matrix, but this finding should be further confirmed by larger studies.
|
30652828 |
2019 |